Document Detail


Single cell analytics: an overview.
MedLine Citation:
PMID:  21072695     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The research field of single cell analysis is rapidly expanding, driven by developments in flow cytometry, microscopy, lab-on-a-chip devices, and many other fields. The promises of these developments include deciphering cellular mechanisms and the quantification of cell-to-cell differences, ideally with spatio-temporal resolution. However, these promises are challenging as the analytical techniques have to cope with minute analyte amounts and concentrations. We formulate first these challenges and then present state-of-the-art analytical techniques available to investigate the different cellular hierarchies-from the genome to the phenome, i.e., the sum of all phenotypes.
Authors:
Hendrik Kortmann; Lars M Blank; Andreas Schmid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in biochemical engineering/biotechnology     Volume:  124     ISSN:  1616-8542     ISO Abbreviation:  Adv. Biochem. Eng. Biotechnol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307733     Medline TA:  Adv Biochem Eng Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  99-122     Citation Subset:  IM    
Affiliation:
Laboratory of Chemical Biotechnology, Department of Biochemical and Chemical Engineering, TU Dortmund University, Emil-Figge-Str. 66, 44221, Dortmund, Germany.
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