Document Detail


Single Arc Volumetric Modulated Arc Therapy for Complex Brain Gliomas: Is There an Advantage as Compared to Intensity Modulated Radiotherapy or by Adding a Partial Arc?
MedLine Citation:
PMID:  22376134     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective of this study was to determine if volumetric modulated arc therapy (VMAT) offers advantages over intensity modulated radiotherapy (IMRT) for complex brain gliomas and evaluate the role of an additional partial arc. Twelve patients with glioma involving critical organs at risk (OAR) were selected [six low grade brainstem glioma (BG) and six glioblastoma (GB) cases]. BGs were prescribed 54 Gy/30 fractions (frx), and GB treated to 50 Gy/30 frx to a lower dose PTV (PTV50) with a simultaneous integrated boost delivering a total dose of 60 Gy/30 frx to a higher dose PTV (PTV60). VMAT was planned with a single arc (VMAT1) and with an additional coplanar partial arc spanning 90° (VMAT2). We observed VMATI improving the PTV equivalent uniform dose (EUD) for BG cases (p= 0.027), improving the V95 for the PTV50 in GB cases (p 5 0.026) and resulting in more conformal GB plans (p= 0.008) as compare to IMRT. However, for the GB PTV60, IMRT achieved favorable V95 over VMAT1 and VMAT2 (0.0046 and 0.008, respectively). The GB total integral dose (ID) was significantly lower with VMAT1 and VMAT2 (p= 0.049 and p= 0.006, respectively). Both VMAT1 and VMAT2 reduced the ID, however, only at the 5 Gy threshold for BG cases (p= 0.011 and 0.005, respectively). VMAT achieved a lower spinal cord maximum dose and EUD for BG cases and higher optic nerve doses, otherwise no significant differences were observed. VMAT1 yielded the fastest treatment times and least MU. We conclude that VMAT offers faster treatment delivery for complex brain tumors while maintaining similar dosimetric qualities to IMRT. Selective dosimetric advantages in terms of spinal cord sparing and lowering the ID are observed favoring the use of an additional coplanar partial arc.
Authors:
M T Davidson; G L Masucci; M Follwell; S J Blake; W Xu; D J Moseley; P Sanghera; C S Wong; J Perry; M Tsao; A Sahgal
Related Documents :
16236144 - Activity of d,l-alpha-tocopherol (vitamin e) against cardiotoxicity induced by doxorubi...
22398964 - Dosing rationale for fixed-dose combinations in children: shooting from the hip?
22843364 - Dosimetric evaluation of the impacts of different heterogeneity correction algorithms o...
22477834 - Bivalirudin use in an infant with persistent clotting on unfractionated heparin.
21496454 - Effect of pregnane x receptor (pxr) prototype agonists on chemoprotective and drug meta...
1365654 - Contribution of associative and nonassociative processes to the development of morphine...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-1
Journal Detail:
Title:  Technology in cancer research & treatment     Volume:  -     ISSN:  1533-0338     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140941     Medline TA:  Technol Cancer Res Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medical Physics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Arjun.Sahgal@sunnybrook.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adjustment of Ultrasound Exposure Duration to Microbubble Sonodestruction Kinetics for Optimal Cell ...
Next Document:  WOMAC-pf as a measure of physical function in patients with Parkinson's disease and late-onset seque...