Document Detail


Simvastatin may improve myocardial perfusion abnormality in slow coronary flow.
MedLine Citation:
PMID:  17934268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The slow coronary flow (SCF) phenomenon is a coronary microvascular disorder characterized by the delayed passage of contrast in the absence of obstructive epicardial coronary disease. Recent studies showed the possible role of endothelial dysfunction, diffuse atherosclerosis and inflammation in the pathogenesis of this phenomenon. We aimed to investigate the effect of statin on myocardial perfusion in patients with SCF. METHODS AND RESULTS: The study population consisted of 97 patients with SCF. Coronary flow patterns of the cases are determined by thrombolysis in myocardial infarction (TIMI) frame count method. Single-photon emission computed tomographic myocardial perfusion imaging studies and lipid parameters of the patients were obtained before and after 6 months of simvastatin treatment period. During the study, daily single dose of 40 mg simvastatin has been given to each subject. We found a significant positive correlation between mean TIMI frame count and basal reversibility score (r = 0.84, p = 0.0001). In addition, analysis of the reversibility scores demonstrates that simvastatin treatment has significantly improved the myocardial perfusion abnormality at the end of the follow-up period. CONCLUSION: Present findings allow us to conclude that simvastatin improved myocardial perfusion in patients with SCF.
Authors:
Mahmut Cakmak; Halil Tanriverdi; Nazmiye Cakmak; Harun Evrengul; Sebnem Cetemen; Omur Kuru
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Publication Detail:
Type:  Journal Article     Date:  2007-10-10
Journal Detail:
Title:  Cardiology     Volume:  110     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Siyami Ersek Cardiac and Thoracic Surgery Center, Istanbul, Turkey. cakmakmn@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Angina Pectoris / diagnosis,  drug therapy*
Blood Chemical Analysis
Blood Flow Velocity / drug effects
Chest Pain / diagnosis,  drug therapy
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Angiography
Coronary Circulation / drug effects*
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Middle Aged
Probability
Prospective Studies
Risk Assessment
Simvastatin / administration & dosage*
Statistics, Nonparametric
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 79902-63-9/Simvastatin

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