Document Detail

Simvastatin maintains steady patterns of GFR and improves AER and expression of slit diaphragm proteins in type II diabetes.
MedLine Citation:
PMID:  16710349     Owner:  NLM     Status:  MEDLINE    
The factors determining the course of glomerular filtration rate (GFR) and albumin excretion rate (AER) and the expression of mRNA of slit diaphragm (SD) and podocyte proteins in microalbuminuric, hypertensive type II diabetic patients are not fully understood. GFR, AER, and SD protein mRNA were studied in 86 microalbuminuric, hypertensive, type II diabetics at baseline and after 4-year random double-blind treatment either with 40 mg simvastatin (Group 1) or with 30 g cholestyramine (Group 2) per day. Both groups had at baseline a GFR decay per year in the previous 2-4 years of 3 ml/min/1.73 m(2). Both Groups 1 and 2 showed a significant decrease of low-density lipoprotein cholesterol levels after simvastatin and cholestyramine treatment (P<0.01). No change from base line values was observed as for hs-C-reactive protein and interleukin-6. A significant decrease of 8-hydroxydeoxyguanosine urinary excretion was observed after simvastatin treatment. GFR did not change from baseline with simvstatin, whereas a decrease was observed with cholestyramine treatment (simvastatin vs cholestyramine: -0.21 vs -2.75 ml/min/1.73 m(2), P<0.01). AER decreased in Group 1 (P<0.01), but not in Group 2 patients. Real-time polymerase chain reaction measurement of mRNA SD proteins (CD2AP, FAT, Actn 4, NPHS1, and NPHS2) significantly increased in kidney biopsy specimens after simvastatin, but not cholestyramine treatment. Simvastatin, but not cholestyramine, 4-year treatment maintains steady patterns of GFR, and improves AER and expression of SD proteins in type II diabetes, despite similar hypocholesterolemic effects in circulation.
G Tonolo; M Velussi; E Brocco; C Abaterusso; A Carraro; G Morgia; A Satta; R Faedda; A Abhyankar; H Luthman; R Nosadini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-17
Journal Detail:
Title:  Kidney international     Volume:  70     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-08-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-86     Citation Subset:  IM    
U.O. Diabetologia, Asl, Olbia, Italy.
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MeSH Terms
Albumins / analysis
Albuminuria / drug therapy*
Anticholesteremic Agents / administration & dosage*
Cholestyramine Resin / administration & dosage
Deoxyguanosine / analogs & derivatives,  urine
Diabetes Mellitus, Type 2 / metabolism*,  pathology
Glomerular Filtration Rate / drug effects*
Kidney Glomerulus / chemistry,  drug effects,  pathology
Lipids / blood
Middle Aged
Podocytes / drug effects,  metabolism
Proteins / genetics,  metabolism*
RNA, Messenger / analysis,  metabolism
Simvastatin / administration & dosage*
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Albumins; 0/Anticholesteremic Agents; 0/Lipids; 0/Proteins; 0/RNA, Messenger; 11041-12-6/Cholestyramine Resin; 79902-63-9/Simvastatin; 961-07-9/Deoxyguanosine

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