| Simvastatin inhibits acidic extracellular pH-activated, outward rectifying chloride currents in RAW264.7 monocytic-macrophage and human peripheral monocytes. | |
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MedLine Citation:
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PMID: 19084616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular acidic pH activated chloride channels (I(Cl,acid)) have been characterized in HEK 293 cells and mammalian cardiac myocytes. This study was designed to evaluate the expression of I(Cl,acid) in RAW264.7 monocytic-macrophage and human peripheral monocytes and to investigate the effect of simvastatin on I(Cl,acid). In two kinds of cells, the activation and deactivation of the current rapidly and repeatedly followed the change of the extracellular solution to pH=4.3. Compared with the outward current (pA/pF) activated at pH 4.3, the currents inhibited by simvastatin at concentrations of 0.1 microM were all decreased a little, however the currents at concentrations of 1 microM and 10 microM simvastatin were decreased significantly. The IC(50) for simvastatin inhibiting I(Cl,acid) of RAW264.7 was 13.77 microM. In summary, we report for the first time that simvastatin inhibits the I(Cl,acid) of RAW264.7 monocytic-macrophage and human peripheral monocytes in a concentration-dependent manner. |
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Authors:
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Cheng-Yao Shi; Rong Wang; Chun-Xi Liu; Hao Jiang; Zhi-Yong Ma; Li Li; Wei Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-11 |
Journal Detail:
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Title: International immunopharmacology Volume: 9 ISSN: 1878-1705 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 247-52 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, QiLu Hospital, Shandong University, Jinan 250012, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Chloride Channels / antagonists & inhibitors* Humans Hydrogen-Ion Concentration Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Macrophages / drug effects*, metabolism Mice Monocytes / drug effects*, metabolism Simvastatin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Chloride Channels; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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