| Simvastatin-induced changes in circulating oxidized low-density lipoprotein in different types of dyslipidemia. | |
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MedLine Citation:
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PMID: 20676836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beyond lowering lipid levels, 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitors (statins) have been shown to possess antioxidant properties, which may explain some of their beneficial effects in reducing atherosclerosis. We sought to determine whether circulating oxidized low-density lipoprotein (ox-LDL) levels differ between subjects with isolated hypercholesterolemia and combined hyperlipidemia, as well as the effect of simvastatin on circulating ox-LDL according to the type of dyslipidemia. Twenty-five subjects with total cholesterol >200 mg/dl and triglycerides <150 mg/dl, and 22 subjects with total cholesterol >200 mg/dl and triglycerides >150 mg/dl were treated with 40 mg simvastatin daily for 3 months. Serum lipids, C-reactive protein, fibrinogen, ox-LDL, and free radicals were measured at baseline and after 3 months of treatment. In both groups studied, simvastatin significantly improved lipids, and reduced C-reactive protein and fibrinogen levels. Free radicals were significantly reduced only in subjects with hypercholesterolemia. Subjects with combined hyperlipidemia had significantly higher baseline levels of ox-LDL compared to those with hypercholesterolemia (64.6 U/l vs 53.5 U/l, P = 0.03). Ox-LDL levels were reduced by 12% in subjects with hypercholesterolemia (P = 0.03) and by 26% in subjects with combined hyperlipidemia (P = 0.001) after simvastatin treatment. In conclusion, subjects with combined hyperlipidemia have increased levels of circulating ox-LDL compared to subjects with isolated hypercholesterolemia. Simvastatin significantly reduced circulating ox-LDL in both groups, but whether this reduction is related to clinical outcomes remains to be shown. |
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Authors:
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Anna Tavridou; Apostolos Efthimiadis; Ioannis Efthimiadis; Vangelis G Manolopoulos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-31 |
Journal Detail:
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Title: Heart and vessels Volume: 25 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 288-93 Citation Subset: IM |
Affiliation:
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Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece. atavrid@med.duth.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood C-Reactive Protein / metabolism Chi-Square Distribution Cholesterol / blood Female Fibrinogen / metabolism Free Radicals / blood Greece Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / blood, drug therapy* Hyperlipidemia, Familial Combined / blood, drug therapy* Lipoproteins, LDL / blood* Male Middle Aged Simvastatin / therapeutic use* Time Factors Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Free Radicals; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipoproteins, LDL; 0/Triglycerides; 0/oxidized low density lipoprotein; 57-88-5/Cholesterol; 79902-63-9/Simvastatin; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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