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Simvastatin has beneficial effect on pulmonary artery hypertension by inhibiting NF-κB expression.
MedLine Citation:
PMID:  21465237     Owner:  NLM     Status:  Publisher    
Whether Simvastatin has beneficial effect on pulmonary artery hypertension (PAH) remains unclear. This study aimed to explore the effect of simvastatin on PAH and the underlying mechanism. Male SD rats were randomized into three groups: control group, PAH model group, and treatment group with the intervention of the Simvastatin (n = 10, each group). Rat PVSMCs were isolated from pulmonary artery, cultured in vitro, and subjected to different treatment with PDGF, and/or Simvastatin or parthenolide. The mean pulmonary arterial pressure (mPAP), endomembrane proliferation in the pneumono-arteriole, and scores of the average angiemphraxis (VOS) were measured. The expression of NF-κB at mRNA and protein levels in the artery and PVSMCs was evaluated by fluorescent quantitative PCR, immunohistochemistry, and Western blot. Our results showed that mPAP, endomembrane proliferation in the pneumono-arteriole and VOS increased significantly in PAH model group compared with control group (P < 0.05). NF-κB expression was significantly higher in PAH model group than control group (P < 0.05), and also higher in the stimulated PVSMCs than control PVSMCs (P < 0.05). With the intervention of simvastatin, mPAP, endomembrane proliferation in the pneumono-arteriole and VOS decreased dramatically, compared with model group (P < 0.05). NF-κB expression was significantly decreased in both the artery and PVSMCs (P < 0.05). In conclusion, our study provides experimental evidence that NF-κB plays an important role in the occurrence of pulmonary artery hypertension and Simvastatin has beneficial effect on pulmonary artery hypertension by inhibiting the expression of NF-κB.
Zhong-Qiang Liu; Bing Liu; Li Yu; Xiao-Qing Wang; Juan Wang; Han-Min Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  -     ISSN:  1573-4919     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Emergency, West China the Second Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
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