| Simvastatin attenuates sympathetic hyperinnervation to prevent atrial fibrillation during post-myocardial infarction remodeling process. | |
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MedLine Citation:
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PMID: 22984252 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Statin, as an HMG-CoA reductase inhibitor, has been shown to prevent atrial fibrillation due to its anti-inflammatory and anti-oxidant effects. However, it is still not know whether statin can improve autonomic remodeling to prevent atrial fibrillation. In the present study, using an in vivo rat myocardial infarction (MI) model, we aimed to test whether simvastatin can attenuate nerve sprouting and sympathetic hyperinnervation to prevent atrial fibrillation during post-myocardial infarction remodeling process. Our data demonstrate that simvastatin delivered 3 days after myocardial infarction for four weeks can result in significant decreases in plasma levels of both TNF-α(239±23 pg/ml) and IL-1β (123±11 pg/ml) compared with MI rats without therapy (TNF-α, 728±57 pg/ml; IL-1β, 213±21 pg/ml. P<0.05, respectively), which, however, were still higher than sham operated rats (TNF-α, 194±20 pg/ml; IL-1β, 75±8 pg/ml. P<0.05, respectively). The similar pattern of changes in inflammation responses was also observed in TNF-α and IL-1β protein expression in left atrium free wall. The suppressed inflammation responses were associated with reduced superoxide and MDA generation in the atrium. These changes account for decreases in neural growth factor expression at levels of both mRNA (1.2±0.09AU vs. MI group, 1.78±0.16AU) and protein (1.57±0.17AU vs. MI group, 2.24±0.19AU) (P<0.05, respectively), thus, resulting in reduced nerve sprouting and sympathetic hyperinnervation. Accordingly, the rate adaptation of atrial effective refractory period also recovered, leading to the decreased inducibility of atrial fibrillation. These data suggest that simvastatin administration after MI can prevent atrial fibrillation through reduced sympathetic hyperinnervation. |
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Authors:
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Tao Yu; Wei Zhu; Beiyin Gu; Shuai Li; Fabing Wang; Mingya Liu; Meng Wei; Jingbo Li |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Shanghai Jiaotong University School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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