Document Detail

Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography.
MedLine Citation:
PMID:  17084257     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We investigated whether simvastatin attenuates plaque inflammation by using 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) co-registered with computerized tomography. BACKGROUND: Inflammation plays a key role in progression and destabilization of atherosclerotic plaque. 18F-fluorodeoxyglucose PET is a promising tool for visualizing inflammation of atherosclerotic plaque. Antiinflammatory action is one of the pleiotropic effects of statins. METHODS: Forty-three consecutive subjects, who underwent 18FDG-PET for cancer screening and had 18FDG uptakes in the thoracic aorta and/or the carotid arteries, were randomized to either statin group receiving simvastatin (n = 21) or diet group receiving dietary management only (n = 22). The maximum standardized uptake values (SUVs) were measured in individual plaques, and were averaged for analysis of the subjectwise results. The responses were assessed after 3-month treatments. RESULTS: Positron emission tomography revealed 117 and 123 18FDG-positive plaques in the statin and diet groups, respectively. Simvastatin, but not diet alone, attenuated plaque (18)FDG uptakes and decreased the SUVs (p < 0.01). Simvastatin reduced low-density lipoprotein cholesterol (LDL-C) by 30% (p < 0.01) and increased high-density lipoprotein cholesterol (HDL-C) by 15% (p < 0.01), whereas LDL-C and HDL-C levels were not changed in the diet group. In the statin group, the decrease in the SUV was well correlated with the HDL-C elevation (p < 0.01) but not with the LDL-C reduction. CONCLUSIONS: 18F-fluorodeoxyglucose PET visualized plaque inflammation and simvastatin attenuated it. The LDL-C-independent effects of simvastatin may participate in the beneficial effect. 18F-fluorodeoxyglucose PET has a potential for visually monitoring plaque inflammation and the therapeutic effectiveness of statins.
Nobuhiro Tahara; Hisashi Kai; Masatoshi Ishibashi; Hiroyuki Nakaura; Hayato Kaida; Kenkichi Baba; Naofumi Hayabuchi; Tsutomu Imaizumi
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-10-17
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  48     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2006-12-04     Revised Date:  2007-07-31    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1825-31     Citation Subset:  AIM; IM    
Department of Medicine/Cardiovascular Research Institute, Division of Cardio-Vascular Medicine, Kurume University School of Medicine, Kurume, Japan.
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MeSH Terms
Aorta, Thoracic / pathology,  radionuclide imaging
Atherosclerosis / drug therapy*,  pathology,  radionuclide imaging*
Carotid Stenosis / drug therapy,  pathology,  radionuclide imaging
Fluorodeoxyglucose F18 / diagnostic use*
Follow-Up Studies
Inflammation / drug therapy,  radionuclide imaging
Middle Aged
Positron-Emission Tomography / methods*
Prospective Studies
Simvastatin / therapeutic use*
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18; 79902-63-9/Simvastatin
Comment In:
J Am Coll Cardiol. 2007 May 15;49(19):1991; author reply 1991-2   [PMID:  17498586 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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