Document Detail


Simultaneous voltammetric determination of ascorbic acid, dopamine and uric acid using polybromothymol blue film-modified glassy carbon electrode.
MedLine Citation:
PMID:  20522988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A sensitive and selective electrochemical method for simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA) using an electropolymerized bromothymol blue (BTB)-modified glassy carbon electrode (GCE) was developed. The electrochemically synthesized film was investigated using electrochemical impedance spectroscopy and voltammetric methods. The electrochemical behavior of the polymer-modified electrode depends on film thickness, i.e., the electropolymyerization time. The poly-BTB-modified GCE shows excellent electrocatalytic activity toward the oxidation of AA, DA, and UA in phosphate buffer solution (pH 5.0). The voltametric peak separations of AA/DA, DA/UA, and AA/UA on this modified electrode are 118 mV, 298 mV, and 455 mV, respectively. Therefore the voltammetric responses of these three compounds can be resolved well on the polymer-modified electrode, and simultaneous determination of these three compounds can be achieved. In addition, this modified electrode can be successfully applied to determine AA and DA in injection and UA in urine samples without interference.
Authors:
Xiongwei Xu; Qihuang Lin; Ailin Liu; Wei Chen; Xiuhua Weng; Changlian Wang; Xinhua Lin
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  58     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-28     Revised Date:  2011-03-08    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, P. R. China.
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MeSH Terms
Descriptor/Qualifier:
Ascorbic Acid / analysis*
Biosensing Techniques / methods*
Bromthymol Blue / analogs & derivatives
Carbon / chemistry
Dopamine / analysis*
Electrochemistry / methods*
Electrodes
Humans
Polymers / chemistry
Sensitivity and Specificity
Uric Acid / analysis*,  urine
Chemical
Reg. No./Substance:
0/Polymers; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid; 7440-44-0/Carbon; 76-59-5/Bromthymol Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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