| Simultaneous voltammetric determination of ascorbic acid, dopamine and uric acid using polybromothymol blue film-modified glassy carbon electrode. | |
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MedLine Citation:
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PMID: 20522988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A sensitive and selective electrochemical method for simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA) using an electropolymerized bromothymol blue (BTB)-modified glassy carbon electrode (GCE) was developed. The electrochemically synthesized film was investigated using electrochemical impedance spectroscopy and voltammetric methods. The electrochemical behavior of the polymer-modified electrode depends on film thickness, i.e., the electropolymyerization time. The poly-BTB-modified GCE shows excellent electrocatalytic activity toward the oxidation of AA, DA, and UA in phosphate buffer solution (pH 5.0). The voltametric peak separations of AA/DA, DA/UA, and AA/UA on this modified electrode are 118 mV, 298 mV, and 455 mV, respectively. Therefore the voltammetric responses of these three compounds can be resolved well on the polymer-modified electrode, and simultaneous determination of these three compounds can be achieved. In addition, this modified electrode can be successfully applied to determine AA and DA in injection and UA in urine samples without interference. |
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Authors:
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Xiongwei Xu; Qihuang Lin; Ailin Liu; Wei Chen; Xiuhua Weng; Changlian Wang; Xinhua Lin |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 58 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-28 Revised Date: 2011-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 788-93 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, P. R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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analysis* Biosensing Techniques / methods* Bromthymol Blue / analogs & derivatives Carbon / chemistry Dopamine / analysis* Electrochemistry / methods* Electrodes Humans Polymers / chemistry Sensitivity and Specificity Uric Acid / analysis*, urine |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid; 7440-44-0/Carbon; 76-59-5/Bromthymol Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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