Document Detail

Simultaneous very late stent thrombosis in multiple coronary arteries.
MedLine Citation:
PMID:  23109755     Owner:  NLM     Status:  MEDLINE    
We report 2 noteworthy cases of very late stent thrombosis presenting as ST-segment-elevation myocardial infarction, with vastly different manifestations. Both patients were women who had histories of multivessel percutaneous coronary intervention with first-generation sirolimus-eluting stents, in 2005 and 2006. On the more recent occasions reported here, one underwent successful multivessel primary percutaneous coronary intervention, while the other underwent successful multivessel "plain old balloon angioplasty." Both were discharged from the hospital with advice to stop smoking and to follow a lifelong regimen of aspirin and clopidogrel.On the basis of these two cases and our review of the current literature, we ask whether it is now prudent to recommend lifelong dual antiplatelet therapy after drug-eluting stent deployment. Moreover, in order to account for cases of stent thrombosis that occur ≥ 5 years after drug-eluting stent implantation, should we perhaps suggest the addition of "extremely late stent thrombosis" to the existing Academic Research Consortium classification?
Seshasayee Narasimhan; Nassim Rostane Krim; Gary Silverman; Ernest Scott Monrad
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  39     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-04-10     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  630-4     Citation Subset:  IM    
Department of Medicine, Cardiovascular Division, Montefiore-Einstein Heart Center, Jack D. Weiler Hospital of the Albert Einstein College of Medicine, Bronx, New York 10461, USA.
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MeSH Terms
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation
Cardiovascular Agents / administration & dosage
Coronary Angiography / methods
Coronary Artery Disease / radiography,  therapy*
Coronary Thrombosis / etiology*,  radiography
Drug Administration Schedule
Drug Therapy, Combination
Drug-Eluting Stents*
Middle Aged
Myocardial Infarction / etiology
Percutaneous Coronary Intervention / adverse effects*,  instrumentation*
Platelet Aggregation Inhibitors / administration & dosage
Sirolimus / administration & dosage
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Cardiovascular Agents; 0/Platelet Aggregation Inhibitors; 53123-88-9/Sirolimus

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