| Simultaneous stimulation of growth hormone, adrenocorticotropin and cortisol with L-dopa/L-carbidopa and propranolol in children of short stature. | |
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MedLine Citation:
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PMID: 10830457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 59 otherwise healthy children of short stature, the simultaneous response of growth hormone, cortisol and plasma adrenocorticotropin (ACTH) to L-dopa/L-carbidopa and propranolol at 45 and 90 min after administration were investigated. A growth hormone response of 10 microg/l or higher was considered positive. The definition of a positive cortisol response included either a hormone increase of at least 193 nmol/l or a peak hormone level of at least 497 nmol/l. The ACTH increase had to be fourfold above 11 pmol/l to be considered positive. In the 59 investigated children, the median basal growth hormone levels increased from 1.35 microg/l to 18.05 microg/l and 10.15 microg/l at 45 and 90 min after stimulation (p < 0.05). The median cortisol levels rose from 242 nmol/l to 439 nmol/l and 612 pmol/l, and the corresponding median ACTH levels from 2.94 pmol/l to 9.63 pmol/l and 11.13 pmol/l at 45 and 90 min after stimulation. Significant positive hormone response rates were 88.1% for growth hormone, 88.1% for cortisol and 69% for ACTH. These results could be attributed to the enhanced stimulating effect of the additional administration of L-carbidopa and propranolol. We conclude that the administration of L-dopa/L-carbidopa and propranolol is useful for the simultaneous evaluation of growth hormone, cortisol and ACTH secretion in children of short stature. |
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Authors:
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H Philippi; J Pohlenz; W Grimm; T Koffler; W Schönberger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 89 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-09-08 Completed Date: 2000-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 442-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Johannes Gutenberg University, Mainz, Germany. philippi@kinder.klinik.uni-mainz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenocorticotropic Hormone / blood, secretion* Carbidopa / pharmacology* Child Child, Preschool Dopamine Agents / pharmacology* Drug Synergism Female Growth Disorders / diagnosis, metabolism* Growth Hormone / blood, secretion* Humans Hydrocortisone / blood, secretion* Levodopa / pharmacology* Male Pituitary Function Tests / methods* Propranolol / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Levodopa; 38821-49-7/Carbidopa; 50-23-7/Hydrocortisone; 525-66-6/Propranolol; 9002-60-2/Adrenocorticotropic Hormone; 9002-72-6/Growth Hormone |
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