Document Detail


Simultaneous staining of sister chromatid exchanges and Q-bands in human chromosomes after treatment with methyl methane sulphonate, quinacrine mustard, and quinacrine.
MedLine Citation:
PMID:  478538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human peripheral lymphocyte chromosomes were stained simultaneously for sister chromatid exchanges (SCEs) and Q-banding. No effect of treatment with MMS, QM, and Q on the distribution of SCEs in chromosomes was found compared with controls. The SCEs were distributed between chromosomes roughly according to metaphase length, with the shorter chromosomes underrepresented. The majority of SCEs were located to pale bands, while a few occurred in bright bands and at interfaces between pale and bright bands. A greater frequency than expected of SCEs had occurred at identical sites in homologous chromosomes. This frequency was significantly increased after treatment with MMS.
Authors:
U Haglund; L Zech
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  49     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  307-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromosome Banding*
Chromosomes, Human / ultrastructure*
Crossing Over, Genetic*
Humans
Methyl Methanesulfonate / pharmacology
Quinacrine / pharmacology
Quinacrine Mustard / pharmacology
Sister Chromatid Exchange*
Chemical
Reg. No./Substance:
4213-45-0/Quinacrine Mustard; 66-27-3/Methyl Methanesulfonate; 83-89-6/Quinacrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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