Document Detail


Simultaneous spectrophotometric estimation of haloperidol and trihexyphenidyl in tablets.
MedLine Citation:
PMID:  20838539     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The combination of haloperidol and trihexyphenidyl is a dosage form to be used as antidyskinetic agent. Literature revealed that there is no single method for the simultaneous estimation of these drugs in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive spectrophotometric method. The simultaneous estimation method is based on the principle of additivity of absorbance, for the determination of haloperidol and trihexyphenidyl in tablet formulation. The absorption maxima of the drugs were found to be at 245.0 nm and 206.0 nm respectively for haloperidol and trihexyphenidyl in methanol and 0.1N HCl (90:10). The obeyance of Beer Lambert's law was observed in the concentration range of 2.5-12.5 µg/ml for haloperidol and 1.0-5.0 µg/ml for trihexyphenidyl. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.
Authors:
S P Wate; A A Borkar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pharmaceutical sciences     Volume:  72     ISSN:  1998-3743     ISO Abbreviation:  Indian J Pharm Sci     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7809431     Medline TA:  Indian J Pharm Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  265-7     Citation Subset:  -    
Affiliation:
Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110, India.
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