| Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques. | |
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MedLine Citation:
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PMID: 20812297 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression (GA-PLS), and principal components-artificial neural network (PC-ANN) analysis were investigated for their application to the simultaneous determination of chlordiazepoxide and clidinium levels in pharmaceuticals. A set of synthetic mixtures of drugs in ethanol and 0.1 M HCL was made, and the prediction abilities of the aforementioned methods were examined using RSE% (relative standard error of the prediction). The PLS and PC-ANN methods were found to be comparable, and GA-PLS produced slightly better results. The predictive models that we built were successfully applied to simultaneously determine the levels of chlordiazepoxide and clidinium in coated tablets. |
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Authors:
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Mohammad Reza Khoshayand; Hamid Abdollahi; Ali Moeini; Ali Shamsaie; Alireza Ghaffari; Sepideh Abbasian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug testing and analysis Volume: 2 ISSN: 1942-7611 ISO Abbreviation: Drug Test Anal Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101483449 Medline TA: Drug Test Anal Country: England |
Other Details:
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Languages: eng Pagination: 430-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Drug and Food Control, Tehran University of Medical Sciences, Iran. khoshayand@tums.ac.ir |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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