Document Detail

Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques.
MedLine Citation:
PMID:  20812297     Owner:  NLM     Status:  In-Process    
Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression (GA-PLS), and principal components-artificial neural network (PC-ANN) analysis were investigated for their application to the simultaneous determination of chlordiazepoxide and clidinium levels in pharmaceuticals. A set of synthetic mixtures of drugs in ethanol and 0.1 M HCL was made, and the prediction abilities of the aforementioned methods were examined using RSE% (relative standard error of the prediction). The PLS and PC-ANN methods were found to be comparable, and GA-PLS produced slightly better results. The predictive models that we built were successfully applied to simultaneously determine the levels of chlordiazepoxide and clidinium in coated tablets.
Mohammad Reza Khoshayand; Hamid Abdollahi; Ali Moeini; Ali Shamsaie; Alireza Ghaffari; Sepideh Abbasian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug testing and analysis     Volume:  2     ISSN:  1942-7611     ISO Abbreviation:  Drug Test Anal     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101483449     Medline TA:  Drug Test Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  430-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Department of Drug and Food Control, Tehran University of Medical Sciences, Iran.
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