Document Detail


Simultaneous single unit recording in the mitral cell layer of the rat olfactory bulb under nasal and tracheal breathing.
MedLine Citation:
PMID:  15977406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Odor perception depends on the odorant-evoked changes on Mitral/Tufted cell firing pattern within the olfactory bulb (OB). The OB exhibits a significant "ongoing" or spontaneous activity in the absence of sensory stimulation. We characterized this ongoing activity by simultaneously recording several single neurons in the mitral cell layer (MCL) of anesthetized rats and determined the extent of synchrony and oscillations under nasal and tracheal breathing. We recorded 115 neurons and found no significant differences in the mean firing rates between both breathing conditions. Surprisingly, nearly all single units exhibited a long refractory period averaging 14.4 ms during nasal respiration that was not different under tracheal breathing. We found a small incidence (2% of neurons) of gamma band oscillations and a low incidence (8.1%) of correlated firing between adjacent MCL cells. During nasal respiration, a significant oscillation at the respiratory rate was observed in 12% of cells that disappeared during tracheal breathing. Thus, in the absence of odorants, MCL cells exhibit a long refractory period, probably reflecting the intrinsic OB network properties. Furthermore, in the absence of sensory stimulation, MCL cell discharge does not oscillate in the gamma band and the respiratory cycle can modulate the firing of these cells.
Authors:
María de la Luz Aylwin; Eugenia Díaz; Pedro E Maldonado
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological research     Volume:  38     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-27     Completed Date:  2005-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  Chile    
Other Details:
Languages:  eng     Pagination:  13-26     Citation Subset:  IM    
Affiliation:
CENI, Iniciativa Científica Milenio y Programas de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile. maylwin@med.uchile.cl
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Female
Male
Neurons / physiology*
Odors
Olfactory Bulb / cytology*,  physiology
Olfactory Pathways / physiology
Oscillometry
Rats
Rats, Sprague-Dawley
Respiration
Smell / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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