Document Detail

Simultaneous simulation of two different concentration time curves in vitro.
MedLine Citation:
PMID:  3856564     Owner:  NLM     Status:  MEDLINE    
A model for in-vitro simultaneous simulation of two different patterns of pharmacokinetic parameters was developed. In the first compartment the initial concentration simulates that seen after intravenous infusion or bolus injection and the antibiotic is diluted at a constant rate. In the second compartment the concentration rises from zero to a maximum of 1/4 the maximum of the first concentration. From this second compartment the drug is diluted at a slower rate.
P M Shah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  15 Suppl A     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-05-14     Completed Date:  1985-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / metabolism*,  pharmacology
Cefotaxime / analogs & derivatives,  metabolism
Models, Biological*
Reg. No./Substance:
0/Anti-Bacterial Agents; 63527-52-6/Cefotaxime; 65085-01-0/Cefmenoxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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