Document Detail


Simultaneous release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus described by dimensionless equations.
MedLine Citation:
PMID:  21485300     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow of the dissolution medium was investigated. Physical parameters corresponding to the dissolution process as the mass transfer coefficient, the thickness of the boundary diffusion layer and the concentration of the saturated solution at this layer were calculated. The results of release were described by dimensionless equations.
Authors:
Regina Kasperek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  68     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-04-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  261-72     Citation Subset:  IM    
Affiliation:
Department of Applied Pharmacy, Medical University of Lublin, 1 Chodźki St., 20-093 Lublin, Poland. regina.kasperek@umlub.pl
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