Document Detail

Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats--effects of bladder outlet obstruction and intravesical PGE2.
MedLine Citation:
PMID:  17565725     Owner:  NLM     Status:  MEDLINE    
AIMS: A method was developed and evaluated to simultaneously register intraabdominal pressure (IAP) and intravesical pressure (IVP) during cystometry in conscious rats. In addition, IAP and IVP were recorded in rats with experimental detrusor overactivity (DO). METHODS: Sprague Dawley rats (n = 24) were used. Six female rats were subjected to partial bladder outlet obstruction for 2 weeks. A catheter was implanted into the bladder to record the IVP, and a balloon-fitted catheter was positioned in the abdominal cavity to record the IAP. PGE(2) was given intravesically to induce DO. Detrusor pressure (DP) was defined as the IVP corrected for IAP. RESULTS: Recorded as increases in IAP, all rats of both sexes exhibited abdominal straining during every void. In controls, a maximal IAP of 6.0 +/- 1.4 cmH(2)O (range 3-15 cmH(2)O) was registered (n = 12) at the time of the flow pressure (FP). Intravesical administration of PGE(2) or BOO did not affect the IAP at basal pressure, FP or micturition pressure. Changes in IAP due to movement or non-voiding-related straining were subtracted from IVP to generate DP and to visualize DO after BOO or intravesical PGE(2). CONCLUSIONS: The conscious rat uses abdominal straining during voiding, and maximal IAP is recorded at the onset of urinary flow. Simultaneous registration of IAP and IVP during the micturition cycle in conscious rats is a convenient method for accurate quantification of pressures inside the bladder and for studying "true" DO without interference from movement artifacts.
Tack Lee; Karl-Erik Andersson; Tomi Streng; Petter Hedlund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurourology and urodynamics     Volume:  27     ISSN:  0733-2467     ISO Abbreviation:  Neurourol. Urodyn.     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303326     Medline TA:  Neurourol Urodyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-95     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley-Liss, Inc.
Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden.
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MeSH Terms
Abdominal Muscles / physiology
Dinoprostone / pharmacology*
Disease Models, Animal
Oxytocics / pharmacology*
Rats, Sprague-Dawley
Urinary Bladder / drug effects,  physiology*
Urinary Bladder Neck Obstruction / physiopathology*
Urinary Bladder, Overactive / physiopathology
Urination / physiology
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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