Document Detail

Simultaneous recording of tissue PCO2, interstitial pH and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period.
MedLine Citation:
PMID:  2573850     Owner:  NLM     Status:  MEDLINE    
Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equal to 7.2 to pH approximately equal to 6.5, K+e to rise from approximately equal to 2.4 up to a maximum of approximately equal to 39 mmol/l, and PtCO2 to increase from approximately equal to 52 to approximately equal to 80 mmHg. Lactate increased from 2 to 5 mmol/kg tissue weight during anoxia and did not fall significantly after re-oxygenation for 10 min. A marked relationship existed between changes in PtCO2 and H+e. After re-oxygenation, K+e (extracellular potassium ion activity) and PtCO2 returned to the pre-anoxic level in a few minutes, whereas H+e took approximately equal to 30 min to recover. H+e recovered in a biphasic manner; a rapid decrease lasting approximately equal to 1 min preceded a much slower phase. We propose that the biphasic normalization of H+e after anoxia mainly reflects an initial and rapid washout of CO2 from brain tissue and a subsequent slow elimination of lactic acid occurring via metabolism and removal by the circulation.
M Ohno; T P Obrenovitch; N Hartell; S Barratt; H S Bachelard; L Symon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurological research     Volume:  11     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-01-08     Completed Date:  1990-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, UK.
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MeSH Terms
Carbon Dioxide / metabolism*
Cerebral Cortex / metabolism,  physiopathology*
Hydrogen-Ion Concentration
Hypercapnia / metabolism
Hypoxia, Brain / metabolism*
Lactates / metabolism*
Lactic Acid
Potassium / metabolism*
Rats, Inbred Strains
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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