| Simultaneous recording of multifocal VEP responses to short-wavelength and achromatic stimuli. | |
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MedLine Citation:
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PMID: 20499134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A paradigm is introduced that allows for simultaneous recording of the pattern-onset multifocal visual evoked potentials (mfVEP) to both short-wavelength (SW) and achromatic (A) stimuli. There were 5 sets of stimulus conditions, each of which is defined by two semi-concurrently presented stimuli, A64/SW (a 64% contrast achromatic stimulus and a short-wavelength stimulus), A64/A8 (64% achromatic/8% achromatic), A0/A8 (0% (gray) achromatic/8% achromatic), A64/A0 and A0/SW. When paired with A64 as part of A64/SW, the SW stimulus yielded mfVEP responses (SWmfVEP) with diminished amplitude in the fovea, consistent with the known sensitivity of the S-cone system. In addition, when A8, which is approximately equal to the L and M cone contribution of the SW stimulus, was recorded alone, the response to A8 was small, but significantly larger than noise. However, when A8 was paired with A64, the response to A8 was reduced to close to noise level, suggesting that the LM cone contribution of the SWmfVEP can be suppressed by A64. When A64 was recorded alone, the response to A64 was about 32% larger than the mfVEP for A64 when paired with the SW. Likewise, the presence of A64 stimulus also reduces the response of SWmfVEP by 35%. Finally, an intense narrow-band yellow background prolonged the latency of SW response for the A0/SW stimulus but not the latency of SW response for the A64/SW stimulus. These results indicate that it is possible to simultaneously record an SWmfVEP with little LM cone contribution along with an achromatic mfVEP. |
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Authors:
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Xian Zhang; Min Wang; Donald C Hood |
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Publication Detail:
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Type: Journal Article Date: 2010-05-25 |
Journal Detail:
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Title: Documenta ophthalmologica. Advances in ophthalmology Volume: 121 ISSN: 1573-2622 ISO Abbreviation: Doc Ophthalmol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-13 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 0370667 Medline TA: Doc Ophthalmol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 93-102 Citation Subset: IM |
Affiliation:
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Radiology Department, Columbia University, Neurological Institute B41, 710 W. 168th Street, New York, NY 10032, USA. xz63@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cone Opsins / radiation effects* Evoked Potentials, Visual / physiology, radiation effects* Humans Middle Aged Photic Stimulation Principal Component Analysis Retina / physiology, radiation effects* Visual Fields Visual Pathways Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY002115-33/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cone Opsins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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