Document Detail


Simultaneous reconstruction of continuous hand movements from primary motor and posterior parietal cortex.
MedLine Citation:
PMID:  23274645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary motor cortex (MI) and parietal area PE both participate in cortical control of reaching actions, but few studies have been able to directly compare the form of kinematic encoding in the two areas simultaneously during hand tracking movements. To directly compare kinematic coding properties in these two areas under identical behavioral conditions, we recorded simultaneously from two chronically implanted multielectrode arrays in areas MI and PE (or areas 2/5) during performance of a continuous manual tracking task. Monkeys manually pursued a continuously moving target that followed a series of straight-line movement segments, arranged in a sequence where the direction (but not length) of the upcoming segment varied unpredictably as each new segment appeared. Based on recordings from populations of MI (31-143 units) and PE (22-87 units), we compared hand position and velocity reconstructions based on linear filters. We successfully reconstructed hand position and velocity from area PE (mean r (2) = 0.751 for position reconstruction, r (2) = 0.614 for velocity), demonstrating trajectory reconstruction from each area. Combing these populations provided no reconstruction improvements, suggesting that kinematic representations in MI and PE encode overlapping hand movement information, rather than complementary or unique representations. These overlapping representations may reflect the areas' common engagement in a sensorimotor feedback loop for error signals and movement goals, as required by a task with continuous, time-evolving demands and feedback. The similarity of information in both areas suggests that either area might provide a suitable target to obtain control signals for brain computer interface applications.
Authors:
Benjamin A Philip; Naveen Rao; John P Donoghue
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-29
Journal Detail:
Title:  Experimental brain research     Volume:  225     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  361-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Biomechanical Phenomena
Brain Mapping*
Feedback, Physiological
Hand / physiology*
Macaca mulatta
Microelectrodes
Motor Cortex / cytology,  physiology*
Movement / physiology*
Neurons / physiology
Parietal Lobe / cytology,  physiology*
Psychomotor Performance / physiology
Statistics as Topic
Time Factors
Grant Support
ID/Acronym/Agency:
R01 NS025074/NS/NINDS NIH HHS; R01 NS025074-21A1/NS/NINDS NIH HHS; T32 MH020068/MH/NIMH NIH HHS
Comments/Corrections

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