Document Detail


Simultaneous real-time echocardiographic imaging of myocardial perfusion and regional function using color-encoded, contrast-enhanced power modulation.
MedLine Citation:
PMID:  14652605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesized that color-encoded, contrast-enhanced, power modulation imaging could allow simultaneous quantification of myocardial perfusion and regional left ventricular function. We studied 12 anesthetized, closed-chest pigs at baseline, during acute ischemia, and during reperfusion, and 8 patients after acute myocardial infarction. Color kinesis was used to color encode endocardial motion during real-time contrast perfusion imaging with high-energy ultrasound pulses. Wall motion was assessed by calculating regional fractional area changes. Translation-free perfusion analysis was performed in automatically identified myocardial regions of interest. Steady-state intensity and postimpulse rate of contrast replenishment were calculated. In all animals, ischemia caused reversible changes in the images and the perfusion- and function-calculated indices. A significant decrease in pixel intensity (14%) and contrast replenishment rate (66%) in left anterior descending coronary artery segments, in agreement with fluorescent microspheres measurements, coincided with a decrease in fractional area change (34%). For patients, respective perfusion and function indices were 61%, 51%, and 58% lower in segments where perfusion defects, regional wall-motion abnormalities, or both were noted in gray scale images. Color-encoded, contrast-enhanced power modulation allows simultaneous real-time imaging and quantitative analysis of myocardial perfusion and regional left ventricular function.
Authors:
Victor Mor-Avi; Claudia E Korcarz; Keith A Collins; Jeanne M Decara; Enrico G Caiani; Roberto M Lang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  16     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1258-66     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Chicago, IL 60637, USA. vmoravi@medicine.bsd.uchicago.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Echocardiography, Doppler, Color*
Feasibility Studies
Fluorocarbons / diagnostic use
Image Enhancement
Image Processing, Computer-Assisted*
Male
Microspheres
Myocardial Infarction / physiopathology,  ultrasonography*
Myocardial Ischemia / physiopathology,  ultrasonography*
Myocardium / metabolism*
Swine
Ventricular Function, Left*
Chemical
Reg. No./Substance:
0/Definity; 0/Fluorocarbons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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