Document Detail


Simultaneous quantification of myocardial perfusion, oxidative metabolism, cardiac efficiency and pump function at rest and during supine bicycle exercise using 1-11C-acetate PET--a pilot study.
MedLine Citation:
PMID:  20662878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: PET using 1-(11)C-acetate (ACE-PET) applied at rest is used for measuring absolute myocardial blood flow (MBF) and oxidative metabolic rate (k(mono)). We evaluated the feasibility of quantitative ACE-PET during exercise. METHODS: Five endurance athletes underwent dynamic PET scanning at rest and during supine bicycle stress. Exercise was maintained at a workload of 120 Watt for 17 min. The rate-pressure product (RPP) was recorded repeatedly. MBF, k(mono) in left (LV) and right (RV) ventricular wall, cardiac output (CO), cardiac efficiency and a lung uptake value reflecting left heart diastolic pressures were calculated from the PET data using previously validated models. RESULTS: MBF increased from 0.71 +/- 0.17 to 2.48 +/- 0.25 ml min(-1) per ml, LV-k(mono) from 0.050 +/- 0.005 to 0.146 +/- 0.021 min(-1), RV-k(mono) from 0.023 + 0.006 to 0.087 + 0.014 min(-1), RPP from 4.7 +/- 0.8 to 13.2 +/- 1.4 mmHg x min(-1) x 10(3) and Cardiac Output from 5.2 +/- 1.1 to 12.3 +/- 1.2 l min (-1) (all P < 0.001). Cardiac efficiency was unchanged (P = 0.99). Lung uptake decreased from 1.1 +/- 0.2 to 0.6 +/- 0.1 ml g(-1) (P < 0.001). DISCUSSION: A number of important parameters related to cardiac function can be quantified non-invasively and simultaneously with a short scanning protocol during steady state supine bicycling. This might open up new opportunities for studies of the integrated cardiac physiology in health and early asymptomatic disease.
Authors:
Jens Sörensen; Sven Valind; Lars G Andersson
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  30     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, University Hospital, Uppsala, Sweden. jens.sorensen@medsci.uu.se
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MeSH Terms
Descriptor/Qualifier:
Acetates / diagnostic use*
Bicycling
Blood Pressure
Carbon / diagnostic use*
Cardiac Output
Coronary Circulation*
Exercise Test*
Feasibility Studies
Heart / physiology,  radionuclide imaging*
Heart Rate
Humans
Myocardial Perfusion Imaging / methods*
Myocardium / metabolism*
Oxidation-Reduction
Pilot Projects
Positron-Emission Tomography*
Predictive Value of Tests
Radiopharmaceuticals / diagnostic use*
Supine Position
Sweden
Time Factors
Ventricular Function*
Chemical
Reg. No./Substance:
0/Acetates; 0/Radiopharmaceuticals; 0/carbon-11 acetate; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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