| Simultaneous quantification of myocardial perfusion, oxidative metabolism, cardiac efficiency and pump function at rest and during supine bicycle exercise using 1-11C-acetate PET--a pilot study. | |
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MedLine Citation:
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PMID: 20662878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: PET using 1-(11)C-acetate (ACE-PET) applied at rest is used for measuring absolute myocardial blood flow (MBF) and oxidative metabolic rate (k(mono)). We evaluated the feasibility of quantitative ACE-PET during exercise. METHODS: Five endurance athletes underwent dynamic PET scanning at rest and during supine bicycle stress. Exercise was maintained at a workload of 120 Watt for 17 min. The rate-pressure product (RPP) was recorded repeatedly. MBF, k(mono) in left (LV) and right (RV) ventricular wall, cardiac output (CO), cardiac efficiency and a lung uptake value reflecting left heart diastolic pressures were calculated from the PET data using previously validated models. RESULTS: MBF increased from 0.71 +/- 0.17 to 2.48 +/- 0.25 ml min(-1) per ml, LV-k(mono) from 0.050 +/- 0.005 to 0.146 +/- 0.021 min(-1), RV-k(mono) from 0.023 + 0.006 to 0.087 + 0.014 min(-1), RPP from 4.7 +/- 0.8 to 13.2 +/- 1.4 mmHg x min(-1) x 10(3) and Cardiac Output from 5.2 +/- 1.1 to 12.3 +/- 1.2 l min (-1) (all P < 0.001). Cardiac efficiency was unchanged (P = 0.99). Lung uptake decreased from 1.1 +/- 0.2 to 0.6 +/- 0.1 ml g(-1) (P < 0.001). DISCUSSION: A number of important parameters related to cardiac function can be quantified non-invasively and simultaneously with a short scanning protocol during steady state supine bicycling. This might open up new opportunities for studies of the integrated cardiac physiology in health and early asymptomatic disease. |
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Authors:
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Jens Sörensen; Sven Valind; Lars G Andersson |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 30 ISSN: 1475-097X ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 279-84 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, University Hospital, Uppsala, Sweden. jens.sorensen@medsci.uu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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diagnostic use* Bicycling Blood Pressure Carbon / diagnostic use* Cardiac Output Coronary Circulation* Exercise Test* Feasibility Studies Heart / physiology, radionuclide imaging* Heart Rate Humans Myocardial Perfusion Imaging / methods* Myocardium / metabolism* Oxidation-Reduction Pilot Projects Positron-Emission Tomography* Predictive Value of Tests Radiopharmaceuticals / diagnostic use* Supine Position Sweden Time Factors Ventricular Function* |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Radiopharmaceuticals; 0/carbon-11 acetate; 7440-44-0/Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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