Document Detail

Simultaneous presentation of coronary heart disease in identical twins.
MedLine Citation:
PMID:  18322132     Owner:  NLM     Status:  MEDLINE    
The development of coronary artery disease involves a complex interplay between environmental and genetic factors, with premature coronary artery disease having a strong genetic component. We present the case a pair of monozygotic identical twins presenting near simultaneously with coronary artery disease and identical atherosclerotic lesions despite significant differences in environmental risk factors and being divided geographically by 12,000 miles. This is of enormous importance and not merely curiosity value as it will have implications for the prevention of coronary artery disease, provide an opportunity for the development of new therapeutic strategies, and aid targeted primary prevention through family screening.
A J Turley; V Chen; J A Hall
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  84     ISSN:  1469-0756     ISO Abbreviation:  Postgrad Med J     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-06     Completed Date:  2008-06-16     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-2     Citation Subset:  IM    
Cardiothoracic Division, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK.
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MeSH Terms
Acute Coronary Syndrome / genetics*,  radiography,  therapy
Angina Pectoris / etiology
Coronary Disease / genetics*,  radiography,  therapy
Diseases in Twins*
Middle Aged
Twins, Monozygotic*

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