Document Detail


Simultaneous perfusion and permeability measurements using combined spin- and gradient-echo MRI.
MedLine Citation:
PMID:  23462570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to estimate magnetic resonance imaging-based brain perfusion parameters from combined multiecho spin-echo and gradient-echo acquisitions, to correct them for T₁₋, T₂₋, and T₂₋*-related contrast agent (CA) extravasation effects, and to simultaneously determine vascular permeability. Perfusion data were acquired using a combined multiecho spin- and gradient-echo (SAGE) echo-planar imaging sequence, which was corrected for CA extravasation effects using pharmacokinetic modeling. The presented method was validated in simulations and brain tumor patients, and compared with uncorrected single-echo and multiecho data. In the presence of CA extravasation, uncorrected single-echo data resulted in underestimated CA concentrations, leading to underestimated single-echo cerebral blood volume (CBV) and mean transit time (MTT). In contrast, uncorrected multiecho data resulted in overestimations of CA concentrations, CBV, and MTT. The correction of CA extravasation effects resulted in CBV and MTT estimates that were more consistent with the underlying tissue characteristics. Spin-echo perfusion data showed reduced large-vessel blooming effects, facilitating better distinction between increased CBV due to active tumor progression and elevated CBV due to the presence of cortical vessels in tumor proximity. Furthermore, extracted permeability parameters were in good agreement with elevated T1-weighted postcontrast signal values.
Authors:
Heiko Schmiedeskamp; Jalal B Andre; Matus Straka; Thomas Christen; Seema Nagpal; Lawrence Recht; Reena P Thomas; Greg Zaharchuk; Roland Bammer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-03-06
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  33     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-02     Completed Date:  2013-06-28     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  732-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Blood-Brain Barrier / metabolism,  pathology
Brain / blood supply*,  metabolism,  pathology*
Brain Neoplasms / blood supply*,  metabolism,  pathology*
Capillary Permeability
Cerebrovascular Circulation
Contrast Media / diagnostic use*,  pharmacokinetics
Female
Humans
Magnetic Resonance Angiography / methods*
Male
Middle Aged
Models, Biological
Grant Support
ID/Acronym/Agency:
P41EB015891/EB/NIBIB NIH HHS; R01 EB002711/EB/NIBIB NIH HHS; R01 NS066506/NS/NINDS NIH HHS; R01EB002711/EB/NIBIB NIH HHS; R01EB006526/EB/NIBIB NIH HHS; R01EB008706/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media
Comments/Corrections

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