Document Detail

Simultaneous onset of pemphigus vulgaris in two Turkish siblings.
MedLine Citation:
PMID:  15863864     Owner:  NLM     Status:  MEDLINE    
The etiology of pemphigus vulgaris is still unknown. Reported familial cases are indicators of a genetic aspect of the disease. We report a brother and sister with simultaneous onset of pemphigus vulgaris. The class II antigens, HLA DRB1*04 and DQB1*03 were detected in both patients. The oral mucosa was affected in one them. Elevation of transaminase levels due to azathioprine therapy was observed in these two cases.
Ayşe Kavak; Ilker Aydoğan; Sevim Gönen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  32     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  186-8     Citation Subset:  IM    
Abant Izzet Baysal University, Duzce Medical School, Department of Dermatology, Duzce, Turkey.
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MeSH Terms
Follow-Up Studies
Genetic Predisposition to Disease*
HLA-DQ Antigens / genetics*
HLA-DR Antigens / genetics*
Mouth Mucosa / pathology
Pemphigus / diagnosis*,  genetics*
Polymorphism, Genetic*
Risk Assessment
Severity of Illness Index
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

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