| Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study. | |
| | |
MedLine Citation:
|
PMID: 11337336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Knowledge of cerebral blood flow (CBF) alterations in cases of acute stroke could be valuable in the early management of these cases. Among imaging techniques affording evaluation of cerebral perfusion, perfusion CT studies involve sequential acquisition of cerebral CT sections obtained in an axial mode during the IV administration of iodinated contrast material. They are thus very easy to perform in emergency settings. Perfusion CT values of CBF have proved to be accurate in animals, and perfusion CT affords plausible values in humans. The purpose of this study was to validate perfusion CT studies of CBF by comparison with the results provided by stable xenon CT, which have been reported to be accurate, and to evaluate acquisition and processing modalities of CT data, notably the possible deconvolution methods and the selection of the reference artery. METHODS: Twelve stable xenon CT and perfusion CT cerebral examinations were performed within an interval of a few minutes in patients with various cerebrovascular diseases. CBF maps were obtained from perfusion CT data by deconvolution using singular value decomposition and least mean square methods. The CBF were compared with the stable xenon CT results in multiple regions of interest through linear regression analysis and bilateral t tests for matched variables. RESULTS: Linear regression analysis showed good correlation between perfusion CT and stable xenon CT CBF values (singular value decomposition method: R(2) = 0.79, slope = 0.87; least mean square method: R(2) = 0.67, slope = 0.83). Bilateral t tests for matched variables did not identify a significant difference between the two imaging methods (P >.1). Both deconvolution methods were equivalent (P >.1). The choice of the reference artery is a major concern and has a strong influence on the final perfusion CT CBF map. CONCLUSION: Perfusion CT studies of CBF achieved with adequate acquisition parameters and processing lead to accurate and reliable results. |
| | |
Authors:
|
M Wintermark; J P Thiran; P Maeder; P Schnyder; R Meuli |
Related Documents
:
|
2214356 - Herpes zoster ophthalmicus with delayed contralateral hemiparesis. 7191506 - Computed tomography in hallervorden-spatz disease. 17991066 - Paradoxical cerebral arterial gas embolism: computed tomography findings. 2342746 - Computed tomography of the brain in eclampsia. 10987576 - Pathophysiology of human epilepsy: imaging and physiologic studies. 12349936 - Mammogram synthesis using a 3d simulation. ii. evaluation of synthetic mammogram texture. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Validation Studies |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 22 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-05-04 Completed Date: 2001-07-05 Revised Date: 2008-02-14 |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 905-14 Citation Subset: IM |
Affiliation:
|
Department of Diagnostic and Interventional Radiology, University Hospital, Swiss Federal Institute of Technology, CHUV-BH10, 1011 Lausanne, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cerebrovascular Circulation* Cerebrovascular Disorders / physiopathology, radiography Encephalitis / physiopathology, radiography Female Humans Least-Squares Analysis Male Middle Aged Prospective Studies Reference Values Regression Analysis Tomography, X-Ray Computed / methods*, standards* Xenon / diagnostic use* |
| Chemical | |
Reg. No./Substance:
|
7440-63-3/Xenon |
| Comments/Corrections | |
Comment In:
|
AJNR Am J Neuroradiol. 2001 Jun-Jul;22(6):1018-9
[PMID:
11415891
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reduction of CSF and blood flow artifacts on FLAIR images of the brain with k-space reordered by inv...
Next Document: Benefits of perfusion MR imaging relative to diffusion MR imaging in the diagnosis and treatment of ...