Document Detail


Simultaneous measurement of perfusion and oxygenation changes using a multiple gradient-echo sequence: application to human muscle study.
MedLine Citation:
PMID:  9811138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a magnetic resonance imaging (MRI) technique based on a multiple gradient-echo sequence designed to probe perfusion and oxygenation simultaneously within skeletal muscle. Processing of the images acquired at successive echo times (TEs) generates two functional maps: one of the signal intensity (SI) extrapolated to zero echo time, which is sensitive to perfusion; and a second one of R2*, which reflects oxygenation. An advantage of the processing procedure lies in the selection of tissue of interest through the profile of T2* decay, leading to automatic rejection of pixels containing small vessels. This allows a more specific assessment of tissue perfusion and oxygenation. This technique was demonstrated successfully during post-ischemic reactive hyperemia in human calf. A perfusion peak of 123 mL x 100 g(-)1 x min(-1) was measured immediately after ischemia, whereas R2* value showed an 11.5% decrease at the same time, essentially reflecting blood oxygenation changes. Differences in the time courses of reperfusion and re-oxygenation were observed, oxygenation presenting a slower recovery. The mechanisms responsible for such a differential dynamic response are discussed.
Authors:
V Lebon; P G Carlier; C Brillault-Salvat; A Leroy-Willig
Related Documents :
22850528 - Comparative study of cardiac anatomic measurements obtained by echocardiography and dua...
22825198 - Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast su...
24231818 - Left ventricular pressure gating in ovine cardiac studies: a software-based method.
12939208 - Direct imaging of exercise-induced myocardial ischemia with fluorine-18-labeled deoxygl...
11587058 - The role of nuclear medicine in breast cancer detection: functional breast imaging.
19107158 - Improving the system stability of a digital shack-hartmann wavefront sensor with a spec...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  16     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  721-9     Citation Subset:  IM    
Affiliation:
Service Hospitalier Frédéric Joliot, CEA, Orsay, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Echo-Planar Imaging / methods*
Humans
Hyperemia / metabolism,  physiopathology
Ischemia / metabolism,  physiopathology
Microcirculation / physiology
Muscle, Skeletal / blood supply*,  metabolism*
Oxygen / metabolism*
Oxygen Consumption
Plethysmography
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  3D fast FLAIR: a CSF-nulled 3D fast spin-echo pulse sequence.
Next Document:  MRI in the study of distal primary myopathopies and of muscular alterations due to peripheral neurop...