Document Detail

Simultaneous measurement of perfusion and oxygenation changes using a multiple gradient-echo sequence: application to human muscle study.
MedLine Citation:
PMID:  9811138     Owner:  NLM     Status:  MEDLINE    
We have developed a magnetic resonance imaging (MRI) technique based on a multiple gradient-echo sequence designed to probe perfusion and oxygenation simultaneously within skeletal muscle. Processing of the images acquired at successive echo times (TEs) generates two functional maps: one of the signal intensity (SI) extrapolated to zero echo time, which is sensitive to perfusion; and a second one of R2*, which reflects oxygenation. An advantage of the processing procedure lies in the selection of tissue of interest through the profile of T2* decay, leading to automatic rejection of pixels containing small vessels. This allows a more specific assessment of tissue perfusion and oxygenation. This technique was demonstrated successfully during post-ischemic reactive hyperemia in human calf. A perfusion peak of 123 mL x 100 g(-)1 x min(-1) was measured immediately after ischemia, whereas R2* value showed an 11.5% decrease at the same time, essentially reflecting blood oxygenation changes. Differences in the time courses of reperfusion and re-oxygenation were observed, oxygenation presenting a slower recovery. The mechanisms responsible for such a differential dynamic response are discussed.
V Lebon; P G Carlier; C Brillault-Salvat; A Leroy-Willig
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  16     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  721-9     Citation Subset:  IM    
Service Hospitalier Frédéric Joliot, CEA, Orsay, France.
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MeSH Terms
Echo-Planar Imaging / methods*
Hyperemia / metabolism,  physiopathology
Ischemia / metabolism,  physiopathology
Microcirculation / physiology
Muscle, Skeletal / blood supply*,  metabolism*
Oxygen / metabolism*
Oxygen Consumption
Reg. No./Substance:

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