Document Detail

Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans.
MedLine Citation:
PMID:  10517788     Owner:  NLM     Status:  MEDLINE    
Human airways produce nitric oxide (NO), and exhaled NO increases as expiratory flow rates fall. We show that mixing during exhalation between the NO produced by the lower, alveolar airways (VL(NO)) and the upper conducting airways (VU(NO)) explains this phenomenon and permits measurement of VL(NO), VU(NO), and the NO diffusing capacity of the conducting airways (DU(NO)). After breath holding for 10-15 s the partial pressure of alveolar NO (PA) becomes constant, and during a subsequent exhalation at a constant expiratory flow rate the alveoli will deliver a stable amount of NO to the conducting airways. The conducting airways secrete NO into the lumen (VU(NO)), which mixes with PA during exhalation, resulting in the observed expiratory concentration of NO (PE). At fast exhalations, PA makes a large contribution to PE, and, at slow exhalations, NO from the conducting airways predominates. Simple equations describing this mixing, combined with measurements of PE at several different expiratory flow rates, permit calculation of PA, VU(NO), and DU(NO). VL(NO) is the product of PA and the alveolar airway diffusion capacity for NO. In seven normal subjects, PA = 1.6 +/- 0.7 x 10(-6) (SD) Torr, VL(NO) = 0.19 +/- 0.07 microl/min, VU(NO) = 0.08 +/- 0.05 microl/min, and DU(NO) = 0.4 +/- 0.4 ml. min(-1). Torr(-1). These quantitative measurements of VL(NO) and VU(NO) are suitable for exploring alterations in NO production at these sites by diseases and physiological stresses.
A P Pietropaoli; I B Perillo; A Torres; P T Perkins; L M Frasier; M J Utell; M W Frampton; R W Hyde
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-17     Completed Date:  1999-11-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1532-42     Citation Subset:  IM; S    
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642-8692, USA.
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MeSH Terms
Models, Biological
Nitric Oxide / biosynthesis*
Partial Pressure
Pulmonary Alveoli / metabolism*
Pulmonary Diffusing Capacity / physiology
Respiratory System / metabolism*
Time Factors
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide

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