Document Detail


Simultaneous measurement of left and right ventricular volumes and ejection fraction during dobutamine stress cardiovascular magnetic resonance.
MedLine Citation:
PMID:  21926858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: During cardiovascular stress, if right ventricular (RV) stroke volume exceeds left ventricular (LV) stroke volume, then a large volume of blood is displaced into the pulmonary circulation that may precipitate pulmonary edema. We sought to determine the metrics by which cardiovascular magnetic resonance (CMR) could measure simultaneous displacement of RV and LV stroke volumes during dobutamine stress.
METHODS: Thirteen healthy subjects (5 women) aged 53 ± 10 years without medical conditions and taking no medications underwent 2 CMR examinations at 1.5 T separated by 4 to 8 weeks in which RV and LV stroke volumes were determined during intravenous dobutamine and atropine infused to achieve 80% of the maximum predicted heart rate response for age.
RESULTS: The RV and LV stroke volumes were highly correlated at each level of stress (rest: r = 0.98, P = 0.007; low stress: r = 0.87, P = 0.001; and peak stress: r = 0.88, P = 0.001), and the mean difference in SV at each level of stress (rest, low stress, and peak stress was 0 to 2 mL on examinations 1 and 2.
CONCLUSIONS: Simultaneous change in right and left ventricular stroke volumes can be assessed in a highly reproducible manner throughout the course of dobutamine CMR stress administered to achieve 80% of maximum predicted heart rate response for age. This technology may help identify discrepancies in RV and LV stroke volumes during cardiovascular stress that are associated with the development of pulmonary edema.
Authors:
Sangeeta Mandapaka; Craig A Hamilton; Timothy M Morgan; William Gregory Hundley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  35     ISSN:  1532-3145     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-19     Completed Date:  2011-12-05     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine (Cardiology Section), Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Atropine / diagnostic use
Cardiotonic Agents / diagnostic use*
Dobutamine / diagnostic use*
Exercise Test
Female
Heart Rate / physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Stroke Volume / physiology*
Ventricular Function, Left / physiology*
Ventricular Function, Right / physiology*
Grant Support
ID/Acronym/Agency:
P30 AG021332/AG/NIA NIH HHS; P30-AG21332/AG/NIA NIH HHS; R01 HL076438/HL/NHLBI NIH HHS; R01HL074330/HL/NHLBI NIH HHS; R33 CA121296/CA/NCI NIH HHS; R33CA121296/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine; 51-55-8/Atropine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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