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Simultaneous measurement of concentrations and velocities of submicron species using multicolor imaging and microparticle image velocimetry.
MedLine Citation:
PMID:  20644678     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We propose a novel approach to resolve simultaneously the distributions of velocities and concentration of multiple, submicron species in microfluidic devices using microparticle image velocimetry, and particle counting. Both two-dimensional measurement and three-dimensional analysis of flow fields, from the stacked images, are achieved on applying a confocal fluorescence microscope. The displacements of all seeding particles are monitored to determine the overall velocity field, whereas the multicolor particles are counted and analyzed individually for each color to reveal the distributions of concentration and velocity of each species. A particle-counting algorithm is developed to determine quantitatively the spatially resolved concentration. This simultaneous measurement is performed on a typical T-shaped channel to investigate the mixing of fluids. The results are verified with numerical simulation; satisfactory agreement is achieved. This measurement technique possesses reliability appropriate for a powerful tool to analyze multispecies mixing flows, two-phase flows, and biofluids in microfluidic devices.
Authors:
Jing-Tang Yang; Yu-Hsuan Lai; Wei-Feng Fang; Miao-Hsing Hsu
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Publication Detail:
Type:  Journal Article     Date:  2010-03-15
Journal Detail:
Title:  Biomicrofluidics     Volume:  4     ISSN:  1932-1058     ISO Abbreviation:  Biomicrofluidics     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101293825     Medline TA:  Biomicrofluidics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14109     Citation Subset:  -    
Affiliation:
Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan.
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