| Simultaneous measurement of brain tissue oxygen partial pressure, temperature, and global oxygen consumption during hibernation, arousal, and euthermy in non-sedated and non-anesthetized Arctic ground squirrels. | |
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MedLine Citation:
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PMID: 18722471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study reports an online temperature correction method for determining tissue oxygen partial pressure P(tO2) in the striatum and a novel simultaneous measurement of brain P(tO2) and temperature (T(brain)) in conjunction with global oxygen consumption V(O2) in non-sedated and non-anesthetized freely moving Arctic ground squirrels (AGS, Spermophilus parryii). This method fills an important research gap-the lack of a suitable method for physiologic studies of tissue P(O2) in hibernating or other cool-blooded species. P(tO2) in AGS brain during euthermy (21.22+/-2.06 mmHg) is significantly higher (P=0.016) than during hibernation (13.21+/-0.46 mmHg) suggests brain oxygenation in the striatum is normoxic during euthermy and hypoxic during hibernation. These results in P(tO2) are different from blood oxygen partial pressure P(aO2) in AGS, which are significantly lower during euthermy than during hibernation and are actually hypoxic during euthermy and normoxic during hibernation in our previous study. This intriguing difference between the P(O2) of brain tissue and blood during these two physiological states suggests that regional mechanisms in the brain play a role in maintaining tissue oxygenation and protect against hypoxia during hibernation. |
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Authors:
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Yilong Ma; Shufen Wu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-07-25 |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 174 ISSN: 0165-0270 ISO Abbreviation: J. Neurosci. Methods Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-12 Completed Date: 2008-11-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
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Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska, Fairbanks, AK 99775-7000, United States. ffym1@uaf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Arousal / physiology* Body Temperature Brain / metabolism* Calorimetry, Indirect / methods Consciousness Electrodes, Implanted* Female Hibernation / physiology* Male Oxygen Consumption / physiology* Partial Pressure Sciuridae |
| Grant Support | |
ID/Acronym/Agency:
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1 R15 NS48873-01/NS/NINDS NIH HHS; R15 NS048873-01/NS/NINDS NIH HHS; R15 NS048873-01S1/NS/NINDS NIH HHS; R15 NS048873-01S2/NS/NINDS NIH HHS |
| Comments/Corrections | |
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