Document Detail

Simultaneous measurement of acetylcholine and monoamines by two serial on-line microdialysis systems: effects of methamphetamine on neurotransmitters release from the striatum of freely moving rats.
MedLine Citation:
PMID:  8177495     Owner:  NLM     Status:  MEDLINE    
A rapid and sensitive set-up consisting of a microbore HPLC with electrochemical detection coupled with two serial on-line microdialysis systems was described to simultaneously measure endogenous levels of acetylcholine (ACh), choline (Ch), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxytyramine (3-MT), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in freely moving rats. The validity of the present procedure is demonstrated by analyzing the effect of methamphetamine (2 mg/kg, s.c.) on the increase release of DA, 3-MT, 5-HT, and ACh but without effect in Ch, DOPAC, HVA and 5-HIAA from the striatum of freely moving rat.
T H Tsai; C F Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  166     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-06-09     Completed Date:  1994-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  175-7     Citation Subset:  IM    
National Research Institute of Chinese Medicine, Taipei, Taiwan.
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MeSH Terms
Acetylcholine / analysis,  metabolism*
Biogenic Monoamines / analysis,  metabolism*
Choline / analysis,  metabolism
Chromatography, High Pressure Liquid
Methamphetamine / pharmacology*
Neostriatum / drug effects,  metabolism*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Biogenic Monoamines; 51-84-3/Acetylcholine; 537-46-2/Methamphetamine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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