Document Detail


Simultaneous improvement of minimal-change nephrotic syndrome and anemia with steroid therapy.
MedLine Citation:
PMID:  9884426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 56-year-old man presented with transient anemia in minimal-change nephrotic syndrome. Following nephrotic syndrome, anemia suddenly appeared without renal dysfunction. The anemia might be attributable to hemodilution because of significant correlations between the values of hemoglobin concentration and serum total protein or blood urea nitrogen during the clinical course. A low serum level and a low urinary excretion of erythropoietin were found, and when nephrotic syndrome ameliorated with steroid therapy, urinary erythropoietin excretion and anemia disappeared. This case indicated disappearance of the exponential increase of endogenous erythropoietin in acute anemia in nephrotic syndrome probably due to urinary losses and altered biosynthesis of erythropoietin. We report a case of the simultaneous improvement of both nephrotic syndrome and anemia with steroid therapy.
Authors:
M Yabana; M Kihara; Y Toya; K Tamura; K Matsumoto; N Takagi; S Kamijo; M Ishii; S Umemura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  81     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-03     Completed Date:  1999-03-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  IM    
Affiliation:
2nd Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anemia / complications,  drug therapy*,  urine
Anti-Inflammatory Agents / therapeutic use*
Erythropoietin / urine
Humans
Kidney Function Tests
Male
Middle Aged
Nephrosis, Lipoid / complications,  drug therapy*,  urine
Prednisolone / therapeutic use*
Proteinuria / drug therapy
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 11096-26-7/Erythropoietin; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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