| Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging. | |
| | |
MedLine Citation:
|
PMID: 19412312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions. |
| | |
Authors:
|
Zhongchi Luo; Zhijia Yuan; Yingtian Pan; Congwu Du |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Optics letters Volume: 34 ISSN: 0146-9592 ISO Abbreviation: Opt Lett Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-04 Completed Date: 2009-07-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
|
Languages: eng Pagination: 1480-2 Citation Subset: IM |
Affiliation:
|
Departments of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794-8181, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Volume Brain Ischemia / blood*, physiopathology Cerebral Cortex / blood supply*, physiopathology Cerebrovascular Circulation* Diagnostic Imaging* Hemodynamics* Infrared Rays Lasers* Oxygen / blood* Oxyhemoglobins / metabolism Rats Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
2R01-DK059265/DK/NIDDK NIH HHS; K25-DA021200/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Oxyhemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Off-chip beam steering with a one-dimensional optical phased array on silicon-on-insulator.
Next Document: Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to...