Document Detail

Simultaneous determination of wave speed and arrival time of reflected waves using the pressure-velocity loop.
MedLine Citation:
PMID:  17710460     Owner:  NLM     Status:  MEDLINE    
In a previous paper we demonstrated that the linear portion of the pressure-velocity loop (PU-loop) corresponding to early systole could be used to calculate the local wave speed. In this paper we extend this work to show that determination of the time at which the PU-loop first deviates from linearity provides a convenient way to determine the arrival time of reflected waves (Tr). We also present a new technique using the PU-loop that allows for the determination of wave speed and Tr simultaneously. We measured pressure and flow in elastic tubes of different diameters, where a strong reflection site existed at known distances away form the measurement site. We also measured pressure and flow in the ascending aorta of 11 anaesthetised dogs where a strong reflection site was produced through total arterial occlusion at four different sites. Wave speed was determined from the initial slope of the PU-loop and Tr was determined using a new algorithm that detects the sampling point at which the initial linear part of the PU-loop deviates from linearity. The results of the new technique for detecting Tr were comparable to those determined using the foot-to-foot and wave intensity analysis methods. In elastic tubes Tr detected using the new algorithm was almost identical to that detected using wave intensity analysis and foot-to-foot methods with a maximum difference of 2%. Tr detected using the PU-loop in vivo highly correlated with that detected using wave intensity analysis (r (2) = 0.83, P < 0.001). We conclude that the new technique described in this paper offers a convenient and objective method for detecting Tr, and allows for the dynamic determination of wave speed and Tr, simultaneously.
A W Khir; M J P Swalen; J Feng; K H Parker
Publication Detail:
Type:  Journal Article     Date:  2007-08-21
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  45     ISSN:  0140-0118     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1201-10     Citation Subset:  IM    
Brunel Institute for Bioengineering and The School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK.
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MeSH Terms
Aorta / physiology
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Models, Cardiovascular*
Pulsatile Flow
Ventricular Pressure / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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