Document Detail


Simultaneous determination of pyrethroid and pyrethrin metabolites in human urine by gas chromatography-high resolution mass spectrometry.
MedLine Citation:
PMID:  15639450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new developed gas chromatographic-high resolution mass spectrometric method for the sensitive simultaneous determination of trans-chrysanthemumdicarboxylic acid, cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid, 3-phenoxybenzoic acid and 4-fluoro-3-phenoxybenzoic acid in human urine is presented. These metabolites are biomarkers for an exposure to pyrethrum, allethrin, resmethrin, phenothrin, tetramethrin, cyfluthrin, cypermethrin, deltamethrin or permethrin. Therefore, with the help of this method for the first time a complete assessment of exposure to pyrethroid and pyrethrin insecticides is possible. After acid hydrolysis and extraction with tert-butyl-methyl-ether the residue is derivatized with 1,1,1,3,3,3-hexafluoroisopropanol and analyzed by GC/HRMS in electron impact mode (detection limits < 0.1 microg/l) as well as in negative chemical ionization mode (detection limit < 0.05 microg/l urine).
Authors:
Gabriele Leng; Wolfgang Gries
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  814     ISSN:  1570-0232     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-10     Completed Date:  2005-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-94     Citation Subset:  IM    
Affiliation:
Department of SUA-GHA-GSS, Institute of Biological Monitoring, Bayer Industry Services GmbH and Co. OHG, Building L9, D-51368 Leverkusen, Germany. gabriele.leng.gl@bayerindustry.de
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MeSH Terms
Descriptor/Qualifier:
Gas Chromatography-Mass Spectrometry / methods*
Humans
Pyrethrins / urine*
Reference Standards
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Pyrethrins

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