Document Detail

Simultaneous determination of norepinephrine, uric acid, and ascorbic acid at a screen printed carbon electrode modified with polyacrylic acid-coated multi-wall carbon nanotubes.
MedLine Citation:
PMID:  20395124     Owner:  NLM     Status:  MEDLINE    
A screen printed carbon electrode (SPCE) modified with polyacrylic acid-coated multi-wall carbon nanotubes (PAA-MWCNTs) has been prepared by the dispersion of MWCNTs in PAA aqueous solution via sonication and the followed drop-coating for the simultaneous determination of norepinephrine (NE), uric acid (UA), and ascorbic acid (AA). The presence of PAA inhibited the adsorption of AA owing to the electrostatic repulsion, but was favorable for the affinity adsorption of NE and UA via the ion exchange and hydrogen bonding mechanisms, respectively. This led to the decrease in the oxidation potential of AA and the significantly enhanced oxidation peak currents of NE and UA at the PAA-MWCNTs/SPCE. By cyclic voltammetry and differential pulse voltammetry, the oxidation potentials of NE, UA, and AA at the PAA-MWCNTs/SPCE in a ternary mixture were found to be well resolved so that their simultaneous determination could be achieved. Furthermore, the interaction of NE, UA, and AA with PAA accounted for their electrochemical responses at different pH values. Also, the effect of pH revealed that the oxidation of NE, UA, and AA at the PAA-MWCNTs/SPCE all involved the transfer of two electrons. In addition, by differential pulse voltammetry, the linear dependence of peak current on the concentration was obtained in the ranges of 0-10, 0-30, and 100-1000 microM with the lowest detection limits of 0.131, 0.458, and 49.8 microM for NE, UA, and AA, respectively.
Shih-Hung Huang; Hsiu-Hsien Liao; Dong-Hwang Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-31
Journal Detail:
Title:  Biosensors & bioelectronics     Volume:  25     ISSN:  1873-4235     ISO Abbreviation:  Biosens Bioelectron     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001289     Medline TA:  Biosens Bioelectron     Country:  England    
Other Details:
Languages:  eng     Pagination:  2351-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Chemical Engineering, National Cheng Kung University, No. 1, Ta-Hsueh Rd., Tainan 701, Taiwan.
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MeSH Terms
Acrylic Resins / chemistry*
Ascorbic Acid / analysis*
Biosensing Techniques / instrumentation*
Coated Materials, Biocompatible / chemistry
Complex Mixtures / analysis
Conductometry / instrumentation
Equipment Design
Equipment Failure Analysis
Nanotubes, Carbon / chemistry*
Norepinephrine / analysis*
Reproducibility of Results
Sensitivity and Specificity
Uric Acid / analysis*
Reg. No./Substance:
0/Acrylic Resins; 0/Coated Materials, Biocompatible; 0/Complex Mixtures; 0/Nanotubes, Carbon; 50-81-7/Ascorbic Acid; 51-41-2/Norepinephrine; 69-93-2/Uric Acid; 9003-01-4/carbopol 940

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