| Simultaneous determination of niacinamide, pyridoxine, riboflavin, and thiamine in multivitamin products by high-pressure liquid chromatography. | |
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MedLine Citation:
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PMID: 6453218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A high-pressure liquid chromatographic assay was developed for the determination of four water-soluble vitamins: niacinamide, pyridoxine, thiamine, and riboflavin. The four vitamins are assayed simultaneously in multivitamin products not containing minerals. Thiamine currently is not quantitated in formulations containing minerals because it is not stable under the extraction conditions. The method was applied to the analysis of at least 12 different multivitamin products, including various formulations of sterile products, fluids, compressed tablets, and coated, compressed tablets. The method is stability indicating and is applicable to single-tablet assays. |
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Authors:
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M C Walker; B E Carpenter; E L Cooper |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 70 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Drug Combinations Niacinamide / analysis* Pyridoxine / analysis* Riboflavin / analysis* Thiamine / analysis* Vitamins / administration & dosage, analysis* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Vitamins; 59-43-8/Thiamine; 65-23-6/Pyridoxine; 83-88-5/Riboflavin; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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