Document Detail

Simultaneous determination of niacinamide, pyridoxine, riboflavin, and thiamine in multivitamin products by high-pressure liquid chromatography.
MedLine Citation:
PMID:  6453218     Owner:  NLM     Status:  MEDLINE    
A high-pressure liquid chromatographic assay was developed for the determination of four water-soluble vitamins: niacinamide, pyridoxine, thiamine, and riboflavin. The four vitamins are assayed simultaneously in multivitamin products not containing minerals. Thiamine currently is not quantitated in formulations containing minerals because it is not stable under the extraction conditions. The method was applied to the analysis of at least 12 different multivitamin products, including various formulations of sterile products, fluids, compressed tablets, and coated, compressed tablets. The method is stability indicating and is applicable to single-tablet assays.
M C Walker; B E Carpenter; E L Cooper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  70     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Drug Combinations
Niacinamide / analysis*
Pyridoxine / analysis*
Riboflavin / analysis*
Thiamine / analysis*
Vitamins / administration & dosage,  analysis*
Reg. No./Substance:
0/Drug Combinations; 0/Vitamins; 59-43-8/Thiamine; 65-23-6/Pyridoxine; 83-88-5/Riboflavin; 98-92-0/Niacinamide

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