Document Detail


Simultaneous determination of metronidazole benzoate, methylparaben, and propylparaben by high-performance liquid chromatography.
MedLine Citation:
PMID:  10529896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The simultaneous determination of metronidazole benzoate (MB), methylparaben (MP), and propylparaben (PP) in an oral suspension formulation was developed using high-performance liquid chromatography (HPLC). The method was developed using a Novapak C18 (3.9 x 150 mm, 4 microns) column, methanol-water (50:50, v/v) as the mobile phase and an ultraviolet (UV) detector at 254 nm. The peak area response versus concentration was linear in a concentration range from 40 to 400 micrograms/ml of MB, 0.8 to 8.0 micrograms/ml of MP, and 0.2 to 2.0 micrograms of PP. The correlation coefficients were 0.9997 for MB, 0.9987 for MP, and 0.9983 for PP, with relative standard errors of 1.12%, 1.28%, and 1.67%, respectively.
Authors:
M S Ali; R S Chaudhary; M A Takieddin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  25     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-03     Completed Date:  1999-12-03     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1143-7     Citation Subset:  IM    
Affiliation:
Tabuk Pharmaceutical Manufacturing Company, Kingdom of Saudi Arabia.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents / analysis*
Benzoates / analysis
Chromatography, High Pressure Liquid / methods
Drug Combinations
Drug Stability
Metronidazole / analysis*
Parabens / analysis*
Sensitivity and Specificity
Suspensions
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Benzoates; 0/Drug Combinations; 0/Parabens; 0/Suspensions; 443-48-1/Metronidazole; 94-13-3/propylparaben; 99-76-3/methylparaben

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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