| Simultaneous determination of human and veterinary antibiotics in various environmental matrices by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry. | |
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MedLine Citation:
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PMID: 22625208 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A robust and sensitive analytical method is presented in which 11 classes of antibiotics are simultaneously extracted and determined in surface water, lagoon wastewater, influent, effluent, sediment, manure and sludge. Water samples with different volumes were adjusted to pH 3, added with 0.2g Na(2)EDTA and then extracted using Oasis hydrophilic-lipophilic balance (HLB) cartridges. Extraction of solid samples was carried out by a combination of ultrasonic and vortex mixing using a mixture of acetonitrile and citric buffer at pH 3 as the extraction solution. The extracts of the solid samples were then cleaned-up by a tandem solid phase extraction (SPE) method using a strong anion exchange cartridge (SAX) and a HLB cartridge, followed by analysis using rapid resolution liquid chromatography-tandem mass spectrometry (RRLC-MS/MS) equipped with electrospray ionization source. Among the 50 target compounds, the recoveries in the range of 50-150% were obtained for 39, 40, 36, 40, 38, 33 and 36 antibiotics in the spiked samples of surface water, lagoon wastewater, influent, effluent, sediment, manure and sludge with three concentrations, respectively. Method quantification limits (MQLs) for the target compounds (except sulfaguanidine and sulfanilamide) were in the range of 0.52-5.88ng/L, 2.36-65.8ng/L, 1.73-20ng/L, 1.42-9.52ng/L, 0.64-6.67ng/g (except bacitracin and cloxacillin), 1.33-17.4ng/g (except salinomycin, narasin, monensin, cloxacillin and novobiocin) and 1.50-28.6ng/g (except salinomycin, narasin, monensin and cloxacillin) in surface water, lagoon wastewater, influent, effluent, sediment, manure and sludge, respectively. The developed analytical method was successfully applied in the determination of target compounds in wastewater and sludge samples from Huiyang wastewater treatment plants, and in ground water, lagoon wastewater, manure and sediment collected from a pig farm, in South China. |
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Authors:
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Li-Jun Zhou; Guang-Guo Ying; Shan Liu; Jian-Liang Zhao; Feng Chen; Rui-Quan Zhang; Fu-Qiang Peng; Qian-Qian Zhang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-7 |
Journal Detail:
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Title: Journal of chromatography. A Volume: - ISSN: 1873-3778 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9318488 Medline TA: J Chromatogr A Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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