Document Detail


Simultaneous determination of ascorbic acid, epinephrine, and uric acid by differential pulse voltammetry using poly(p-xylenolsulfonephthalein) modified glassy carbon electrode.
MedLine Citation:
PMID:  20605706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel poly(p-xylenolsulfonephthalein) modified glassy carbon electrode was prepared for the simultaneous determination of ascorbic acid (AA), epinephrine (EP) and uric acid (UA). Cyclic voltammetric, chronoamperometric, and differential pulse voltammetric methods were used to investigate the modified electrode for the electrocatalytic oxidation of EP, AA, and UA in aqueous solutions. The separation of the oxidation peak potentials for AA-EP and EP-UA was about 200 and 130 mV, respectively. The calibration curves obtained for AA, EP, and UA were in the ranges of 10-1343, 2-390, and 0.1-560 micromol L(-1), respectively. The detection limits (S/N=3) were 4, 0.1, and 0.08 micromol L(-1) for AA, EP and UA, respectively. The diffusion coefficient and the catalytic rate constant for the oxidation of EP at the modified electrode were calculated as 1.40(+/-0.10) x 10(-4) cm(2) s(-1) and 1.06 x 10(3) mol(-1) Ls(-1), respectively. The present method was applied to the determination of EP in pharmaceutical and urine samples, AA in commercially available vitamin C tablet, and EP plus UA in urine samples.
Authors:
Ali A Ensafi; M Taei; T Khayamian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-12
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  79     ISSN:  1873-4367     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  480-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran. ensafi@cc.iut.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Ascorbic Acid / analysis*,  urine
Benzenesulfonates / chemistry*
Carbon / chemistry*
Electrochemical Techniques / methods*
Electrodes
Epinephrine / analysis*,  urine
Glass / chemistry*
Humans
Oxidation-Reduction
Polymers / chemistry*
Sulfones / chemistry*
Uric Acid / analysis*,  urine
Chemical
Reg. No./Substance:
0/Benzenesulfonates; 0/Polymers; 0/Sulfones; 0/poly(4-xylenolsulfonephthalein); 50-81-7/Ascorbic Acid; 51-43-4/Epinephrine; 69-93-2/Uric Acid; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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