Document Detail

Simultaneous detection of biomolecular interactions and surface topography using photonic force microscopy.
MedLine Citation:
PMID:  23202338     Owner:  NLM     Status:  Publisher    
We developed a photonic force microscope that can map multiple parameters simultaneously, including the surface topography and biomolecular interactions. To track the position of the probe bead and to determine contact position with the sample surface, we adopted a video analysis method using the diffraction pattern of monochromatic light passing through the probe bead. To demonstrate the capability of the microscope, we report the simultaneous measurement of the molecule distribution of DNA oligonucleotides on the surface, the binding strength of DNA hybridization between the bead and surface, and the topography of the smooth molded surface.
Seungjin Heo; Kipom Kim; Rodriguez Christophe; Tae-Young Yoon; Yong-Hoon Cho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-22
Journal Detail:
Title:  Biosensors & bioelectronics     Volume:  42C     ISSN:  1873-4235     ISO Abbreviation:  Biosens Bioelectron     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001289     Medline TA:  Biosens Bioelectron     Country:  -    
Other Details:
Languages:  ENG     Pagination:  106-111     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Graduate School of Nanoscience & Technology (WCU), KAIST, Daejeon 305-701, Republic of Korea.
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