Document Detail

Simultaneous cardiac output and regional myocardial perfusion determination with PET and nitrogen 13 ammonia.
MedLine Citation:
PMID:  12569328     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to evaluate the possibility of measuring cardiac output during positron emission tomography (PET) examination of myocardial perfusion with nitrogen 13 ammonia. METHODS AND RESULTS: In 7 patients undergoing right-sided cardiac catheterization for evaluation of heart failure and 6 patients who had undergone heart transplantation, a thermodilution catheter for continuous measurement of cardiac output was inserted. An N-13 ammonia scan of the heart was subsequently performed, and with use of factor analysis, the time-activity curve from the right ventricle was derived from the dynamic image sequence. The PET-derived cardiac output was subsequently obtained according to the Stewart-Hamilton principle as the amount of injected tracer divided by the area under the time-activity curve. PET-acquired cardiac output measurements correlated closely with the invasively determined values for a wide range of cardiac output values (P < .0001). The mean difference was 0.12 L/min, with an SD of 0.74 L/min. The interobserver variation was low, with a mean difference of 0.06 L/min and an SD of 0.46 L/min. CONCLUSIONS: Cardiac output determination with N-13 ammonia and PET appears to be both accurate and precise and can be performed simultaneously with measurement of myocardial perfusion.
Jens D Hove; Klaus F Kofoed; Hsiao M Wu; Søren Holm; Lars Friberg; Christian Meyer; Jan Aldershvile; Birger Hesse; Henning Kelbaek
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  10     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-02-05     Completed Date:  2003-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
Cardiovascular PET Research Unit, Department of Cardiology, The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
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MeSH Terms
Ammonia / diagnostic use
Cardiac Output / physiology*
Coronary Circulation / physiology*
Heart Catheterization
Heart Failure / physiopathology,  radionuclide imaging*,  surgery
Heart Transplantation
Linear Models
Middle Aged
Nitrogen Radioisotopes / diagnostic use*
Observer Variation
Reproducibility of Results
Thermodilution / methods
Tomography, Emission-Computed*
Reg. No./Substance:
0/Nitrogen Radioisotopes; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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