Document Detail

Simultaneous attenuation and scatter corrections from the projections in small animal PET imaging.
MedLine Citation:
PMID:  22609114     Owner:  NLM     Status:  Publisher    
Attenuation and scatter corrections are important in quantitative positron emission tomography (PET) imaging even in small animals such as mice and rats. In this work we describe a simple and efficient model to correct for both scatter and attenuation in a single operation. The model aims to solve the equation M=(A+F) P for the primaries P, corrected for attenuation and scatter, based on the measured coincidences M, the matrix of compensation for attenuation A and on the scatter fractions F issued from all emitting sources and contributing to M. The scatter functions are analytically calculated using Klein-Nishina formula, the scanner geometry and the detection efficiencies. This method was applied in measured data of line sources and hot spots phantoms as well as in rat heart and tumors and compared to Monte Carlo based simulations and to the single scatter simulation model developed by Watson et al. The corrected data showed a quantitative contrast and signal to noise ratio enhancement with respect to the uncorrected data. In terms of results, our method is comparable to that of Watson et al. The Monte Carlo simulations, where the primaries and the scattered events were separately registered, confirmed the accuracy of the new approach.
Otman Sarrhini; M'hamed Bentourkia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-19
Journal Detail:
Title:  Computer methods and programs in biomedicine     Volume:  -     ISSN:  1872-7565     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506513     Medline TA:  Comput Methods Programs Biomed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke (QC) J1H 5N4, Canada.
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