Document Detail

Simultaneous assessment of wall motion and coronary flow velocity in the left anterior descending coronary artery during dipyridamole stress echocardiography.
MedLine Citation:
PMID:  12724655     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was designed to assess the feasibility and clinical meaning of simultaneous assessment of wall motion and coronary flow velocity (CFV) reserve in the left anterior descending coronary artery (LAD) by transthoracic approach for detecting LAD stenosis during dipyridamole stress echocardiography. BACKGROUND: Coronary flow reserve plays an important role, which can be evaluated by transthoracic Doppler echocardiography during vasodilator stress. METHODS: Dipyridamole stress test was performed in 110 patients with known or suspected coronary artery disease. CFV in the distal LAD was obtained at baseline and after dipyridamole infusion, and wall motion was also assessed up to the administration of atropine, if required. All patients underwent quantitative coronary angiography within 2 days of the stress test, and significant LAD stenosis was defined as > 50% stenosis. RESULTS: The success rate of both measurements was 92%. CFV reserve < 2 had a higher sensitivity (94% vs 72%, P <.01) and a lower specificity (65% vs 95%, P <.01) than wall-motion assessment for detecting significant LAD stenosis, and diagnostic accuracy between 2 methods was comparable (81% vs 82%). A total of 69 patients (73%) showed concordant results of the 2 methods, and diagnostic accuracy for detecting significant LAD stenosis was high (94%) in this subset of patients. CONCLUSIONS: The simultaneous assessment of CFV and wall motion was feasible in the majority of cases during dipyridamole stress echocardiography. Although diagnostic accuracy between the 2 tests was comparable, concordant results of the 2 methods provided accurate diagnosis in detecting significant LAD stenosis.
Yuichi Nohtomi; Masaaki Takeuchi; Kazushige Nagasawa; Ken-ichi Arimura; Kenji Miyata; Kouichi Kuwata; Tohru Yamawaki; Shoichi Kondo; Akira Yamada; Shuichi Okamatsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  16     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-01     Completed Date:  2003-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  457-63     Citation Subset:  IM    
Department of Cardiovascular Medicine, Cardiovascular Center, Iizuka Hospital, Japan.
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MeSH Terms
Blood Flow Velocity*
Constriction, Pathologic
Coronary Angiography
Coronary Vessels / pathology,  physiology*
Dipyridamole / diagnostic use
Echocardiography, Doppler
Feasibility Studies
Middle Aged
Myocardial Contraction*
Sensitivity and Specificity
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasodilator Agents; 58-32-2/Dipyridamole

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