| Simultaneous assessment of myocardial free fatty acid utilization and left ventricular function using 123I-BMIPP-gated SPECT. | |
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MedLine Citation:
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PMID: 10565779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to evaluate the methodological feasibility of 123I-labeled beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP)-gated SPECT to assess regional and global left ventricular (LV) function in comparison with 99mTc-sestamibi (methoxyisobutyl isonitrile [MIBI])-gated SPECT and first-pass radionuclide angiography (FPRNA). METHODS: Forty-four patients with stable coronary artery disease underwent rest BMIPP-gated SPECT (111 MBq, 60 s/step) and rest MIBI-gated SPECT (600 MBq, 40 s/step) within a week. From both gated SPECT studies, regional defect scores (DS), wall motion scores (WMS) and wall-thickening scores (WTS) were evaluated visually using 4-point scales for nine segments, and LV ejection fraction (EF) (%) was automatically calculated using Quantitative Gated SPECT (QGS) software. FPRNA was also performed on injection of MIBI. RESULTS: Exact agreement between the two gated SPECT studies was 84.1% (kappa = 0.706, r = 0.907, P < 0.0001) in WMS and 87.1% (kappa = 0.662, r = 0.884, P < 0.0001) in WTS. LVEF obtained from BMIPP-gated SPECT linearly correlated with those from MIBI-gated SPECT (y = -0.27 + 0.944x, r = 0.948, SEE = 5.00, P < 0.0001) and FPRNA (y = -7.32 + 1.042x, r = 0.919, SEE = 6.19, P < 0.0001). Even in 21 patients with mismatch segments (BMIPP DS > MIBI DS), agreement was considered to be acceptable in WMS (81.5%, kappa = 0.707, r = 0.853, P < 0.0001) and in WTS (76.7%, kappa = 0.526, r = 0.754, P < 0.0001), and correlation in LVEF remained good between BMIPP-gated SPECT and MIBI-gated SPECT (y = -1.24 + 0.955x, r = 0.938, SEE = 6.25, P < 0.0001) or FPRNA (y = -6.03 + 1.024x, r = 0.913, SEE = 7.38, P < 0.0001). CONCLUSION: BMIPP-gated SPECT can evaluate regional and global LV function with the QGS software. Therefore, BMIPP-gated SPECT offers the opportunity for simultaneous assessment of myocardial free fatty acid utilization and LV function. |
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Authors:
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M Inubushi; E Tadamura; T Kudoh; N Hattori; S Kubo; T Koshiji; K Nishimura; M Komeda; N Tamaki; J Konishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 40 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-09 Completed Date: 1999-12-09 Revised Date: 2006-05-06 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1840-7 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Faculty of Medicine, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Disease / physiopathology, radionuclide imaging Fatty Acids / diagnostic use*, metabolism* Feasibility Studies Female Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Male Myocardium / metabolism* Radiopharmaceuticals / diagnostic use Software Technetium Tc 99m Sestamibi / diagnostic use Tomography, Emission-Computed, Single-Photon / methods* Ventricular Function, Left / physiology* Ventriculography, First-Pass |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 116754-87-1/iodofiltic acid |
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