| Simultaneous assessment of gastric accommodation and emptying: studies with liquid and solid meals. | |
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MedLine Citation:
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PMID: 15235061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously. METHODS: Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration of 185 MBq (5 mCi) (99m)Tc-pertechnetate. After ingestion of 11 MBq (300 micro Ci) (111)In-diethylenetriaminepentaacertic acid in a liquid nutrient drink or an (111)In-oxine-labeled egg sandwich, dual-isotope imaging assessed SPECT gastric dimensions and gastric emptying every 20 min up to 240 min. Gastric accommodation was calculated as the percentage change in planar (2-dimensional) gastric cross-sectional area (CSA) using a left anterior oblique planar projection and the percentage change in total SPECT gastric voxel counts (3-dimensional) compared with the baseline image. RESULTS: With the liquid nutrient drink (9 subjects), maximal mean CSA (158% +/- 12% of baseline; P < 0.05) occurred 40 min after meal ingestion, when only 69% +/- 3% of the radiolabeled liquid nutrient drink remained in the stomach. At 120 min, mean CSA was 125% +/- 8% of baseline, but only 35% +/- 3% of the liquid nutrient drink remained in the stomach. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred 20 min after meal ingestion (189% +/- 25% of baseline). With the solid egg meal (10 subjects), maximal total CSA (159% +/- 13% of baseline) occurred immediately after meal ingestion; total CSA remained significantly increased above baseline for the first 3 h after ingestion of the egg meal, despite only 12% +/- 4% gastric retention at 3 h. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred immediately after the meal (184% +/- 19% of baseline). CONCLUSION: This method permits simultaneous measurement of gastric emptying and accommodation. In healthy subjects, the gastric accommodation response is prolonged and persists despite nearly complete emptying of a liquid or solid meal. |
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Authors:
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Hrair P Simonian; Alan H Maurer; Linda C Knight; Steve Kantor; Despina Kontos; Vasileios Megalooikonomou; Robert S Fisher; Henry P Parkman |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 45 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-05 Completed Date: 2004-08-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1155-60 Citation Subset: IM |
Affiliation:
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Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anatomy, Cross-Sectional / methods* Dyspepsia / physiopathology, radionuclide imaging Female Gastric Emptying / physiology* Gastrointestinal Motility / physiology Humans Image Interpretation, Computer-Assisted / methods* Injections, Intravenous Male Octreotide / administration & dosage, analogs & derivatives*, diagnostic use Organometallic Compounds / administration & dosage, diagnostic use Oxyquinoline / administration & dosage, analogs & derivatives*, diagnostic use Pentetic Acid / administration & dosage, analogs & derivatives*, diagnostic use Phantoms, Imaging Radiopharmaceuticals / administration & dosage, diagnostic use Reproducibility of Results Sensitivity and Specificity Sodium Pertechnetate Tc 99m / administration & dosage, diagnostic use Stomach / physiology*, radionuclide imaging* |
| Grant Support | |
ID/Acronym/Agency:
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DK02921/DK/NIDDK NIH HHS; RR00349/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Organometallic Compounds; 0/Radiopharmaceuticals; 142694-57-3/SDZ 215-811; 14514-42-2/indium oxine; 148-24-3/Oxyquinoline; 23288-60-0/Sodium Pertechnetate Tc 99m; 67-43-6/Pentetic Acid; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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