Document Detail


Simultaneous assessment of gastric accommodation and emptying: studies with liquid and solid meals.
MedLine Citation:
PMID:  15235061     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously. METHODS: Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration of 185 MBq (5 mCi) (99m)Tc-pertechnetate. After ingestion of 11 MBq (300 micro Ci) (111)In-diethylenetriaminepentaacertic acid in a liquid nutrient drink or an (111)In-oxine-labeled egg sandwich, dual-isotope imaging assessed SPECT gastric dimensions and gastric emptying every 20 min up to 240 min. Gastric accommodation was calculated as the percentage change in planar (2-dimensional) gastric cross-sectional area (CSA) using a left anterior oblique planar projection and the percentage change in total SPECT gastric voxel counts (3-dimensional) compared with the baseline image. RESULTS: With the liquid nutrient drink (9 subjects), maximal mean CSA (158% +/- 12% of baseline; P < 0.05) occurred 40 min after meal ingestion, when only 69% +/- 3% of the radiolabeled liquid nutrient drink remained in the stomach. At 120 min, mean CSA was 125% +/- 8% of baseline, but only 35% +/- 3% of the liquid nutrient drink remained in the stomach. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred 20 min after meal ingestion (189% +/- 25% of baseline). With the solid egg meal (10 subjects), maximal total CSA (159% +/- 13% of baseline) occurred immediately after meal ingestion; total CSA remained significantly increased above baseline for the first 3 h after ingestion of the egg meal, despite only 12% +/- 4% gastric retention at 3 h. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred immediately after the meal (184% +/- 19% of baseline). CONCLUSION: This method permits simultaneous measurement of gastric emptying and accommodation. In healthy subjects, the gastric accommodation response is prolonged and persists despite nearly complete emptying of a liquid or solid meal.
Authors:
Hrair P Simonian; Alan H Maurer; Linda C Knight; Steve Kantor; Despina Kontos; Vasileios Megalooikonomou; Robert S Fisher; Henry P Parkman
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  45     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-05     Completed Date:  2004-08-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1155-60     Citation Subset:  IM    
Affiliation:
Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Anatomy, Cross-Sectional / methods*
Dyspepsia / physiopathology,  radionuclide imaging
Female
Gastric Emptying / physiology*
Gastrointestinal Motility / physiology
Humans
Image Interpretation, Computer-Assisted / methods*
Injections, Intravenous
Male
Octreotide / administration & dosage,  analogs & derivatives*,  diagnostic use
Organometallic Compounds / administration & dosage,  diagnostic use
Oxyquinoline / administration & dosage,  analogs & derivatives*,  diagnostic use
Pentetic Acid / administration & dosage,  analogs & derivatives*,  diagnostic use
Phantoms, Imaging
Radiopharmaceuticals / administration & dosage,  diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Sodium Pertechnetate Tc 99m / administration & dosage,  diagnostic use
Stomach / physiology*,  radionuclide imaging*
Grant Support
ID/Acronym/Agency:
DK02921/DK/NIDDK NIH HHS; RR00349/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 0/Radiopharmaceuticals; 142694-57-3/SDZ 215-811; 14514-42-2/indium oxine; 148-24-3/Oxyquinoline; 23288-60-0/Sodium Pertechnetate Tc 99m; 67-43-6/Pentetic Acid; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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