Document Detail

Simultaneous assessment of diameter and pressure waveforms in the carotid artery.
MedLine Citation:
PMID:  14998666     Owner:  NLM     Status:  MEDLINE    
Simultaneous assessment of diameter and pressure waveforms allows the calculation of the incremental compliance, distensibility, pulse wave velocity and elastic modulus as function of the distending pressure. However, the waveforms must be obtained at the same position and acquired and processed with the same filter characteristics to circumvent possible temporal and spatial changes in amplitude and phase. In this paper, arterial diameter waveforms are assessed by means of ultrasound (US) and converted to pressure using an empirically derived exponential relationship between pressure and arterial cross-section. The derived pressure waveform is calibrated to brachial end diastolic and mean arterial pressure by iteratively changing the wall rigidity coefficient (i.e., the exponential power). Because pressure is derived directly from arterial cross-section, no phase delay is introduced due to spatial separation or different filter characteristics. The method was evaluated for the left common carotid artery of 51 healthy subjects ranging in age from 22 to 75 years old. In healthy subjects, the carotid pulse pressure is 29% lower than the brachial pulse pressure. Continuous assessment of arterial properties confirms that pulse-wave velocity and incremental elastic modulus increase, whereas distensibility and compliance decrease, as function of increasing distending blood pressure.
Jan M Meinders; Arnold P G Hoeks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  30     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-04     Completed Date:  2004-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Department of Biophysics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Age Factors
Blood Flow Velocity / physiology
Blood Pressure / physiology
Brachial Artery / physiology
Carotid Artery, Common / anatomy & histology,  physiology,  ultrasonography*
Middle Aged
Pulsatile Flow
Vascular Resistance

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